Peripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy?

Table 2 Growth factors following chemotherapy

Ref.	Disease	Collection strategy	n	CD34+ yield (× 10-6 cell/kg): Median (range)	Failure rates n (%)
Weaver et al[91]	MM ML BC	G-CSF 6 μg/kg per day	49	12 (0.1-54)	2 (4.1)
		GM-CSF 250 μg/m2 per day	49	5.4 (0.02-64)	4 (8.2)
		GM-CSF × 5 d then G-CSF 6 μg/kg per day	52	10.5 (0.4-96)	1 (1.9)
Arora et al[43]	MM	G-CSF 250 μg/m2 per day	35	16.4 (1.1-71.7)	NR
		GM-CSF 250 μg/m2 per day	37	12.8 (0.4-94.5)
Tricot et al[46]	MM	PEG 6 mg q7d × 2	97	NR; no difference	NR
		G-CSF 10 μg/kg per day	140
Fruehauf et al[92]	MM	PEG 12 mg × 1	26	9.7 (4.9-40.5)	3 (11.5)
Steidl et al[93]	MM	PEG 12 mg × 1	12	7.4 (4.9-38)	0
		G-CSF 8.5 μg/kg per day	12	10.8 (5-87)	0

MM: Multiple myeloma; ML: Malignant lymphoma; BC: Breast cancer; G-CSF: Granulocyte colony stimulating factor; GM-CSF: Granulocyte macrophage colony stimulating factor; NR: Not reported; NHL: Non-hodgkin’s lymphoma; PEG: Pegylated filgrastim.