Peripheral blood stem cell mobilization in multiple myeloma: Growth factors or chemotherapy?

Table 1 Growth factor mobilization

Ref.	Disease	Collection strategy	n	CD34+ yield (× 10-6 cell/kg): Median (range)	Failure n (%)
Desikan et al[26]	MM	G-CSF 10-16 μg/kg per day	117	6.2 (0.6-34.1)	NR
Kröger et al[27]	MM	G-CSF 10-24 μg/kg per day	25	3.8 (0.3-17)	3 (12)
Popat et al[31]	MM	G-CSF	302	NR	9%
Pusic et al[90]	MM	G-CSF 10 μg/kg per day	384	4.6	24 (6.3)
	NHL HD	G + C	17	8.5	1 (5.9)
Weaver et al[34]	BC	G-CSF 10 μg/kg per day	14	0.6 (0.1-2.8)	NR
		G-CSF 20 μg/kg per day	13	1 (0.2-5.2)
		G-CSF 30 μg/kg per day	14	2.4 (0.6-6.8)
		G-CSF 40 μg/kg per day	14	1.4 (0.1-4.8)
Weisdorf et al[42]	NHL	GM-CSF 250 μg/m2 per day	16	4.78 (3.02-10.68)	0
	HD	G-CSF 250 μg/m2 per day	15	8.01 (3.17-29)	0
Spitzer et [41]	BC GCT	GCSF 10 mcg/kg per day	26	21.45 (1.63-182.91)	NR
	NHL HD	GCSF 10 mcg/kg per day +	24	13.33 (0.56-102.08)
	MM	GM-CSF 5 mcg/kg per day
Hosing et al[39]	MM	PEG 12 mg × 1	19	8.4 (4.1-15.8)	0
		G-CSF 10 μg/kg per day	8	8.1 (5.17-19.2)	0

MM: Multiple myeloma; G-CSF: Granulocyte colony stimulating factor; NR: Not reported; BC: Breast cancer; NHL: Non-hodgkin’s lymphoma; GM-CSF: Granulocyte macrophage colony stimulating factor; HD: Hodgkin’s disease; GCT: Germ cell tumor; PEG: Pegylated filgrastim.