Lymphocyte recovery is an independent predictor of relapse in allogeneic hematopoietic cell transplantation recipients for acute leukemia

Table 4 Univariable and multivariable risk factors influencing incidence of relapse

IR	Univariable HR (95%CI, P value)	Multivariable HR (95%CI, P value)
Age at HCT	0.97 (0.94-1.01, P = 0.1)	0.13 (0.0096-1.38, P = 0.093)
Single Marital status	2.59 (1.13-6.65, P = 0.023)	0.82 (0.21-3.27, P = 0.77)
AML vs ALL	0.82 (0.36-1.8, P = 0.62)
Female D vs Male R	2.15 (0.91-4.7, P = 0.079)	2.24 (0.88-5.31, P = 0.086)
Match vs Mismatch	1.9 (0.3-6.7, P = 0.42)
MRD vs Other	1.6 (0.47-10, P = 0.49)
D14 ALC > 0.3	0.31 (0.09-0.8, P = 0.014)	0.27 (0.05-0.94, P = 0.038)
MAC vs RIC	1.38 (0.46-3.4, P = 0.53)
CR1 vs other	0.52 (0.23-1.15, P = 0.1)	0.36 (0.15-0.87, P = 0.024)
aGVHD	0.54 (0.16-1.43, P = 0.23)
cGVHD	0.24 (0.079-0.59, P = 0.0013)	0.33 (0.1-0.92, P = 0.035)

ALC: Absolute lymphocyte count; HR: Hazard ratio; CR1: First complete remission; R: Recipient; D: Donor; AML: Acute myeloid leukemia; ALL: Acute lymphoblastic leukemia; cGVHD: Chronic graft vs host disease; MAC: Myeloablative conditioning; RIC: Reduced intensity conditioning; MRD: Matched related donor.