Histopathological analysis of infiltrating T cell subsets in acute T cell-mediated rejection in the kidney transplant

Table 3 Immune infiltrate characteristics and outcomes of the kidney transplant patients

Pati-ent	Group	t	i	v	CD4 (%)	CD8 (%)	CD19 (%)	Granzyme B (cells/mm2)	IL-17 (cells/mm2)	Foxp3 (cells/mm2)	CTL/Treg ratio	Th17/Treg ratio	GFR at Bx	GFR last follow-up	Protei-nuria at Bx	Protei-nuria last follow-up	Time to any rejection (d)	Time to doubling of creatinine (d)	Time to Tx loss (d)	Total follow-up (d)
1	ATCMR	1	3	1	35	25	15	68	5	35	2	0.1	18.5	4.7	4.28	UNK	NA	38	116	116
2	ATCMR	3	2	0	60	60	10	346	2	149	2.3	0	33.6	67.2	0.51	0.16	28	NA	NA	1643
3	ATCMR	2	2	1	30	35	30	31	15	73	0.4	0.2	48.1	30.9	0	UNK	92	NA	NA	1623
4	ATCMR	2	2	0	30	25	30	55	17	56	1	0.3	15.2	9.5	0.41	1.71	NA	NA	513	513
5	ATCMR	3	2	1	85	80	25	544	19	311	1.8	0.1	11.2	15	1.08	1.61	NA	NA	645	645
6	ATCMR	2	1	0	30	15	10	26	52	3	8.8	17.9	30.1	6.7	0.39	UNK	1037	941	1176	1176
7	ATCMR	0	1	1	10	20	10	42	4	6	6.6	0.6	49.8	70.3	0.32	0.09	NA	NA	NA	1327
8	ATCMR	0	2	1	5	10	0	13	0	8	1.5	0	16.9	6.2	2.43	6.66	164	164	164	164
9	ATCMR	2	2	0	10	5	10	4	43	1	4.4	47.4	17.4	14.3	2.34	UNK	NA	NA	759	759
10	ATCMR	1	2	0	35	50	15	81	20	17	4.7	1.2	25.8	8.6	1.53	2.46	404	911	933	933
11	ATCMR	1	1	1	10	5	5	9	22	2	4.7	11.5	112.1	44.7	2.07	0.07	NA	520	NA	950
12	ATCMR	1	2	0	20	15	10	18	5	4	4.8	1.3	16.4	15.1	0.58	UNK	NA	NA	NA	917
13	ATCMR	3	2	0	80	70	20	322	32	35	9.3	0.9	9.2	9.2	1.39	1.39	NA	NA	NA	1
14	ATCMR	2	2	0	20	10	10	38	62	10	3.9	6.3	15.2	8.2	6.09	UNK	NA	NA	NA	913
15	NR	0	1	0	20	15	10	36	55	34	1	1.6	21.1	8.8	6.77	UNK	NA	598	862	862
16	NR	0	1	0	5	10	10	1	5	2	0.5	2.5	43.4	35.8	0.13	1.2	NA	NA	NA	1507
17	NR	0	1	0	5	15	10	5	15	4	1.3	3.8	41.2	63.5	0.39	0.57	NA	NA	NA	1306
18	NR	1	1	0	35	30	30	92	16	32	2.8	0.5	56	9.8	2.4	2.24	NA	974	1118	1118
19	NR	0	1	0	0	5	0	21	2	8	2.7	0.2	64.6	53.2	3.62	7.57	1168	NA	NA	1173
20	NR	1	0	0	20	15	10	25	73	15	1.7	5	28.4	7.1	3.5	UNK	NA	188	520	520
21	NR	1	1	0	25	15	10	81	81	10	8.1	8.1	20.9	12.4	10.59	7.46	NA	141	163	163

ATCMR: Acute T cell-mediated rejection; Bx: Biopsy; GFR: Glomerular filtration rate; HLA: Human leukocyte antigen; i: i score; NA: Not applicable; NR: No rejection; t: t score; Tx: Transplant; UNK: Data unknown; v: v score.