Developing a donation after cardiac death risk index for adult and pediatric liver transplantation

Table 2 Point allocation system for the donor after cardiac death risk index score

Donor/recipient predictor variables	HR (CI)	Points
Primary indication for transplant
Low (P = 0.07)
Standard (P = 0.05)	2 (1-4.04)	2
High (P = 0.04)	2.83 (1.04-7.24)	3
reTPL (P = 0.26)	1.87 (0.63-5.58)	2
MELD > 25 (P = 0.04)	2.75 (1.04-7.24)	3
CIT > 10 h (P = 0.6)	1.37 (0.4-4.04)	1
WIT > 25 min (P = 0.4)	1.48 (0.6-3.63)	1
dHepT
40-60 min (P = 0.5)	1.36 (0.53-3.53)	1
> 60 min (P = 0.05)	4.4 (1.02-19.04)	4

Points were given to each variable in proportion to their calculated hazard ratio (HR). Primary indication for liver transplant has been divided into three risk groups of low, standard and high, as defined by their survival curves. Low DCD risk indications for transplant include autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis, non-alcoholic steatohepatitis, Hepatitis B virus and cholestatic liver disease (primary familial intrahepatic cholestasis, extrahepatic biliary atresia and Crigler Najjar). Standard risk indications were metabolic diseases that included Wilson’s, Hemochromatosis and Familial Amyloid Polyneuropathy. High risk indications for DCD transplant were alcohol related liver disease; HCV: Hepatitis C virus, cryptogenic and Budd Chiari. reTPL: Retransplantation; MELD: Model for end stage liver disease; CIT: Cold ischemic time; WIT: Warm ischemic time; dHepT: Donor hepatectomy time; HCC: Hepatocellular carcinoma.