Biomarkers in renal transplantation: An updated review

Table 8 Analysis of pooled urine proteins collected from patients with acute rejection, BK virus nephropathy, and chronic allograft nephropathy when compared to STA urine with the criteria of > 1.5 fold change of each transplant injury phenotype (acute rejection, BK virus nephropathy, and chronic allograft nephropathy), compared to STA pooled urine and with a P-value of ≤ 0.05[131]

Increased in AR	Increased in BKVN	Increased in CAN
HLA-DRB1, FGB, FGA, FGG, KRT14, HIST1H4B, KRT7, DPP4	KRT18, SUMO2, STMN1, CFHR2, KRT8, KRT19, RPL18, KRT75, FAM3C, HIST1H2BA	CALR, FAM151A, SERPINA2P, FAM3C, DAG1, KITLG, LUM, FABP4, AGT, LRG1

AR: Acute rejection; BKVN: BK virus nephropathy; CAN: Chronic allograft nephropathy; FGB: Fibrinogen beta chain; FGA: Fibrinogen alpha chain; FGG: Fibrinogen gamma chain; KRT14: Keratin 14; HIST1H4B: Histone cluster 1 H4 family member b; KRT7: Keratin 7; DPP4: Dipeptidyl peptidase 4; KRT18: Keratin 18; SUMO2: Small ubiquitin-like modifier 2; STMN1: Stathmin1; CFHR2: Complement factor H related 2; KRT8: Keratin 8; KRT19: Keratin 19; RPL18: Ribosomal protein L18; KRT75: Keratin 75; FAM3C: Family with sequence similarity 3 member C; HIST1H2BA: Histone cluster 1 H2B family member a; CALR: Calreticulin; FAM151A: Family with sequence similarity 151 member A; SERPINA2P: Serpin family A member 2; FAM3C: Family with sequence similarity 3 member C; DAG1: Dystroglycan 1; KITLG: KIT ligand; LUM: Lumican; FABP4: Fatty acid binding protein 4; AGT: Angiotensinogen; LRG1: Leucine rich alpha-2-glycoprotein 1.