Biomarkers in renal transplantation: An updated review

Table 6 Performance of kidney solid organ response test in the acute rejection in renal transplantation AART143, AART124, and AART100 cohorts

kSORT predictions
	AART143 (training set)		AART124 (validation set)		AART100 (cross-validation set)
	AR	No AR	AR	No AR	AR	No AR
Real results						3
AR	39	8	21	2	36	43
No AR	9	87	1	100	3
Sensitivity (95%CI)	82.98% (69.19%-92.35%)		91.30% (71.96%-98.38%)		92.31% (79.13%-98.38%)
Specificity (95%CI)	90.63% (82.95%-95.62%)		99.01% (94.61%-99.97%)		93.48% (82.1%-96.63%)
PPV (95%CI)	81.25% (68.06%-89.81%)		95.46% (78.20%-99.19%)		93.21% (79.68%-97.35%)
NPV (95%CI)	91.58% (84.25%-95.67%)		98.04% (93.13%-99.46%)		93.48% (82.45%-97.76%)
AUC (95%CI)	0.94 (0.91-0.98)		0.95 (0.88-1.00)		0.92 (0.86-0.98)

kSORT: Kidney solid organ response test; AART: Assessment of acute rejection in renal transplantation; AR: Acute rejection; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the curve.