Biomarkers in renal transplantation: An updated review

Table 5 Seventeen genes involved in the study kidney solid organ response test

Symbol	Gene name	Cytoband
Genes derived from the NIH SNSO1 study
DUSP1	Dual-specificity phosphatase 1	5q35.1
NAMPT	Nicotinamide phosphoribosyltransferase	7q22.3
PSEN1	Presenilin 1	14q24.2
MAPK9	Mitogen-activated protein kinase 9	5q35.3
NKTR	Natural killer cell triggering receptor	3p22.1
CFLAR	CASP8 and FADD like apoptosis regulator gene	2q33.1
IFNGR1	Ligand binding chain of the gamma interferon receptor gene	6q23.3
ITGAX	Integrin alphaXchain protein encoding gene	16p11.2
RNF130	Ring finger motif encoding gene	5q35.3
RYBP	RING1 and YY1 binding protein encoding gene	3p13
Genes added to improve the accuracy of kSORT
CEACAM4	Carcinoembryonic antigen related cell adhesion molecule 4	19q13.2
EPOR	Erythropoietin receptor encoding gene	19p13.2
GZMK	Granzyme K encoding gene	5q11.2
RARA	Retinoic acid receptor encoding gene	17q21.2
RHEB	Ras homolog enriched in brain encoding gene	7q36.1
RXRA	Retinoic X receptor alpha encoding gene	9q34.2
SLC25A37	Solute carrier family 25 number 37 encoding gene	8p21.2

The 17 gene set was selected in 143 samples for acute rejection classification and predicted AR up to 3 mo prior to detection by the current gold standard (biopsy). kSORT: Kidney solid organ response test; SNSO1: Steroid-Free vs Steroid-Based Immunosuppression in Pediatric Renal (Kidney) Transplantation.