Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of rapamycin inhibitors in kidney transplant

Table 2 Summary of Different Early Conversion Clinical Trials

Ref.	Study design	Time of conversion	Group 1	Group 2
Everolimus
Budde et al[23], 2011 (ZEUS Study)	Multicentre, Prospective, Randomized Study (n = 300), 12 mo	4.5th month	EVR (C0, 6-10 ng/mL) Induction: Basiliximab (n = 155)	CsA (C0, 120-180 ng/mL till 4.5-6 mo then decreased to 100-150 ng/mL) Induction: Basiliximab (n = 145)
Mjörnstedt et al[24], 2012 (CENTRAL trial)	Multicentre, Prospective, Randomized Study, (n = 269), 12 mo	7th week	EVR (C0, 6-10 ng/mL) + MMF (1.4 g/d till 2 wk then decreased to 1.08 g/d) + S (n = 92)	Low CsA (C0, 75-200 ng/mL till 2 wk then decreased to 50-150 ng/mL) + MMF (1.4 g/d) + S (n = 90)
Sirolimus
Lebranchu et al[25], 2009 (CONCEPT Study)	Multicentre Prospective, Randomized Study, (n = 193), 12 mo	3rd month	SRL (C0, 8-15 ng/mL till 39 wk then decreased to 5-10 ng/mL) + MMF + S (Induction: Daclizumab) (n = 95)	CsA (C0, 500-800 ng/mL) + MMF + S (Induction: Daclizumab) (n = 97)
Guba et al[26], 2010 (SMART Trial)	Multicentre Prospective, Randomized Study, (n = 140), 12 mo	10-24th day	SRL (C0, 8-12 ng/mL then decreased to 5-10 ng/mL) + MMF (1.5 g/d) + S (Induction: ATG) (n = 69)	CsA (C0, 150-200 ng/mL then decreased to 100-150 ng/mL) + MMF (2 g/d) + S (Induction: ATG) (n = 71)
Weir et al[27], 2010 (Spare the Nephron Trial)	Multicentre, Prospective, Randomized Study, (n = 299), 12 mo	Within 115 d	MMF + SRL (n = 148)	MMF + CNI (n = 151)
Heilman et al[28], 2011	Multicentre Prospective, Randomized Study, (n = 122), 12 mo	1 mo	SRL (C0, 9.8 ± 3.6 ng/mL) + MMF + S (Induction: Basiliximab) (n = 62)	TAC (C0, 6.9 ± 4.6 ng/mL) + MMF + S (Induction: Basiliximab) (n = 60)