Outcomes in randomized controlled trials of exercise interventions in solid organ transplant

Table 4 International Classification of Functioning, Disability and Health outcome classifications

ICF component	Domain	Category	Outcome measures	Count primary1	Organ group
Body Function	Global mental functions	b134	Sleep quality and quantity	1	Kidney
		b152	Mood status	0	Lung
	Functions of the cardiovascular system (heart functions)	b410	Cardiac output	0	Heart, kidney
		b410	Carotid intima-media thickness	0	Kidney
		b410	Echocardiographic parameters	2	Heart
		b410	Endothelial function	2	Heart
		b410	Left ventricular systolic function	0	Heart
		b410	RR interval	0	Heart
		b410	Stroke volume	0	Heart, kidney
		b410	Systemic vascular endurance	0	Kidney
	Functions of the cardiovascular system (heart rate)	b4100	Heart rate	1	Heart, kidney, lung
		b4100	Heart rate recovery	1	Heart
		b4100	Heart rate reserve	1	Heart
		b4100	Heart rate variability	1	Kidney
	Functions of the cardiovascular system	b410-429	Baroceptor control of blood pressure	1	Heart
		b410-429	Baroceptor control of heart rate	1	Heart
		b410-429	Baroflex effectiveness index	0	Kidney
		b410-429	Baroflex sensitivity	1	Kidney
		b410-429	Chronotropic response index	1	Heart
		b410-429	Total CVD risk	1	Kidney
		b410-429	Cardiac allograft vasculopathy	1	Heart
	Functions of the cardiovascular system (blood vessel	b415	Arterial stiffness	3	Heart, kidney
	functions)	b415	Brachial artery diameter	0	Heart
	Functions of the cardiovascular system (blood	b420	Arterial pressure	0	Kidney
	pressure functions)	b420	Blood pressure	4	Heart, kidney, lung
		b420	Neck pressure	0	Heart
	Functions of the cardiovascular system (oxygen-carrying functions of the blood)	b4301	Arteriovenous oxygen difference	0	Kidney
	Functions of the hematological and immunological	b430-439	Biochemical parameters	0	Heart
	systems	b430-439	Blood calcium level	0	Kidney
		b430-439	Blood creatinine	0	Heart, kidney
		b430-439	Blood electrolytes	0	Kidney
		b430-439	Blood glucose	1	Heart, kidney
		b430-439	Blood lipids	2	Heart, kidney, lung
		b430-439	Blood phosphorus	0	Kidney
		b430-439	Blood protein levels	1	Heart, kidney
		b430-439	Blood urea nitrogen levels	0	Kidney
		b430-439	C-reactive protein	1	Heart
		b430-439	Cholesterol	3	Heart, kidney
		b430-439	Folate concentrations	0	Kidney
		b430-439	Hematocrit	0	Kidney
		b430-439	Hemoglobin	0	Heart, kidney
		b430-439	High sensitive C-reactive protein	0	Heart
		b430-439	Interleukin levels	2	Heart, kidney
		b430-439	Plasma norepinephrine	0	Heart
		b430-439	Soluble cell adhesion molecules	1	Heart
		b430-439	Total-homocysteine	0	Kidney
		b430-439	Tumour necrosis factor-alpha	2	Heart
		B430-439	Tumor necrosis factor receptor	0	Kidney
		b435	Cytomegalovirus IgG status	0	Heart
		b435	White blood cell levels	0	Heart
		b435	Acute rejection episodes	0	Heart, lung
	Functions of the respiratory system (respiration functions)	b440	Forced expiratory volume	0	Lung
	functions)	b440	Forced vital capacity	1	Heart
		b440	Maximum expiratory/inspiratory pressure	0	Heart
		b440	Peak expiratory flow	0	Kidney
		b440	Peak respiratory exchange ratio	1	Heart, kidney, liver, lung
		b440	Respiratory compensation point	0	Heart
		b440	Ventilatory reserve and capacity	0	Lung
	Functions of the respiratory system (respiration rate)	b4400	CO2 production	0	Heart
		b4400	Oxygen uptake at anaerobic threshold	0	Lung
		b4400	Peak ventilation	2	Heart, kidney
		b4400	Peak VO2	13	Heart, kidney, liver, lung
		b4400	Ventilatory equivalent for carbon dioxide and oxygen	1	Heart
	Functions of the respiratory system (respiratory muscle functions)	b445	Respiratory muscle force/strength	1	Heart, lung
	Functions of the cardiovascular system (general physical endurance)	b4550	Rating of perceived exertion	0	Heart, kidney, liver
	Functions related to the digestive, metabolism and the endocrine system	b530	Body mass index	4	Heart, kidney, liver
	endocrine system	b530	Body weight/mass	3	Heart, kidney, liver, lung
		b530	Fat mass/body fat	3	Heart, kidney, liver
		b530	Fat-free mass	1	Heart
		b530	Hip girth	0	Kidney
		b530	Hip-waist ratio	0	Heart
		b530	Lean tissue mass	2	Heart, kidney, liver
		b530	Percent body fat	2	Heart, kidney, liver
		b530	Visceral fat scale	0	Heart
		b530	Waist girth	0	Kidney
	General metabolic functions, unspecified	b5400	Basal metabolic rate	0	Heart
		b5400	Metabolic age	0	Heart
	General metabolic functions, other, specified	B5408	Maximal metabolic units	1	Kidney
	Functions related to metabolism and the endocrine system	b540-559	Enzyme levels	0	Kidney
	system	b540-559	Fetuin A	0	Kidney
		b540-559	Oxidative stress-induced lipid peroxidation	0	Heart
		b540-559	Serum insulin	1	Heart
		b540-559	Serum metabolic and/or hematologic profile	1	Heart
		b540-559	Vitamin B12	0	Kidney
		b540-559	Glycemic control parameters	0	Heart, kidney
		b540-559	Muscle metabolic enzyme activity	1	Heart
		b545	Body water	0	Heart
		b545	Homeostasis model assessment	0	Heart
	Functions of the genitourinary and reproductive functions (urinary functions)	b610-639	Glomerular filtration rate	1	Kidney
	Neuromusculoskeletal and movement-related functions (muscle power functions)	b730	Peak workload/power output	1	Heart, kidney, lung
		b730	Muscle strength	7	Heart, kidney, liver, lung
		b730-b749	Muscle vasodilation	1	Heart
		b740	Muscle endurance	1	Heart
Body structure	Structures related to movement - additional musculoskeletal structures related to movement (bones)	s7700	Bone mass	0	Heart
		s7700	Bone mineral content	1	Heart, kidney, liver
		s7700	Bone mineral density	3	Heart, kidney, liver, lung
		s7700	Total bone calcium	0	Heart
		s7702	Muscle composition (fibre types)	1	Heart
Activities and participation	Mobility - walking and moving	d410	STS-60	0	Kidney
participation	Mobility - walking and moving (walking)	d450	Daily steps	0	Lung
		d450	Daily walking time	1	Lung
		d450	6 Minute Walk Distance	3	Heart, liver, lung
		d450	Anaerobic threshold	1	Heart, lung
	Mobility - walking and moving	d450-469	Daily physical activity	0	Heart
		d450-469	Movement intensity	0	Lung
		d450-469	Self-reported activity level	0	Kidney
		d450-469	Time spent in moderate intense activities	0	Lung
		d450-469	Duke Treadmill Score	0	Heart
		d450-469	Exercise duration	1	Heart, kidney
	Managing diet and fitness	d5701	Caloric intake	0	Heart
		d5701	Nutritional intake	1	Liver
	Major life areas (work and employment)	d840-859	Employment status	1	Kidney
Environmental factors	Products or substances for personal consumption, other specified	e1108	Smoking status	0	Kidney
	Drugs	e1101	Immunosuppression use	0	Kidney
Questionnaires			DASI	0	Kidney
			Quality of Life Profile for Chronic Diseases Questionnaire	1	Lung
			SF-36	8	Heart, kidney, liver, lung
			St. George’s Respiratory Questionnaire	1	Lung
			State-Trait Anxiety Inventory	1	Heart
			Beck Depression Inventory	1	Heart
			Hospital Anxiety and Depression Scale	2	Heart
			Visual Analog Scale (change in HRQoL)	0	Heart
			WHOQOL-BREF	2	Heart, kidney
Not covered by ICF			Chronic Liver Disease Questionnaire	1	Liver
			Incidence of morbidity	0	Kidney, lung
			Adherence to training and follow-up	2	Kidney

¹Count Primary: Count of studies that used this measure as a primary measure. RR-interval: Inter-beat interval (heart rate); CVD: Cardio-vascular disease; STS-60: Sit-to-stand 60; SF-36: Short-form 36; HRQoL: Health-related quality of life; WHOQOL-BREF: A shorter version of the original World Health Organization Quality of Life Questionnaire; DASI: Duke Activity Status Index.