Time spent in hospital after liver transplantation: Effects of primary liver disease and comorbidity

Table 3 Multivariable linear regression analysis for transplant length of stay and later length of stay in the first two years after liver transplantation

Variable value	Coefficient for TLOS			Coefficient for LLOS
	(d)	95%CI	P-value	(d)	95%CI	P-value
Primary liver disease groups1
Cancer	0	Reference	< 0.001	0	Reference	< 0.001
Acute hepatic failure	6.1	2.8, 9.4		4	-3.3, 11.3
Hepatitis C cirrhosis	3.9	1.3, 6.4		5.4	-0.1, 10.9
Primary sclerosing cholangitis	0.2	-2.5, 3.0		8.4	2.6, 14.3
Hepatitis B cirrhosis	1.9	-2.3, 6.1		1	-7.9, 9.9
Primary biliary cirrhosis	-0.5	-3.2, 2.1		0.2	-5.6, 5.9
Alcoholic cirrhosis	0.6	-1.6, 2.8		0.6	-4.1, 5.4
Autoimmune and cryptogenic	0.1	-2.6, 2.9		1.4	-4.4, 7.2
Metabolic liver disease	4.3	0.3, 8.4		7.1	-1.5, 15.7
Other liver disease	5.9	2.8, 9.1		14.8	8.1, 21.5
Comorbidities2
Cardiovascular disease	8.5	5.7, 11.3	< 0.001	6	0.2, 11.9	0.04
Congestive cardiac failure	7.6	3.4, 11.8	< 0.001	-5	-14.0, 3.9	0.27
Connective tissue disease	-1.4	-4.8, 2.0	0.42	2.3	-4.9, 9.5	0.54
Dementia	0.2	-2.9, 3.4	0.87	3.6	-3.1, 10.4	0.29
Diabetes mellitus	1	-0.6, 2.6	0.22	2.6	-0.8, 6.0	0.13
Non-hepatic malignancy	-0.7	-6.7, 5.3	0.82	-0.5	-13.2, 12.2	0.94
Chronic pulmonary disease	1.6	-0.5, 3.8	0.14	4.3	-0.2, 8.9	0.06
Chronic renal disease	1	-1.6, 3.5	0.47	4.8	-0.7, 10.3	0.09

¹A coefficient for primary liver disease groups represents a difference in days between LOS of patients in the primary liver disease group and the reference group (cancer);

²A coefficient for comorbidities represents a difference in days between LOS of patients with and without the comorbidity. The multivariable models were adjusted for primary liver disease group, comorbidities, recipient age, sex, log bilirubin, log creatinine, INR, sodium, transplant centre and time of transplantation. TLOS: Transplant length of stay; LLOS: Later length of stay.