Acute antibody-mediated rejection after intestinal transplantation

Table 4 Pretransplant risk factors for acute antibody-mediated rejection (univariate analysis)

Variables	Non-ABMR (n = 157)	ABMR (n = 18)	OR	95%CI	P
Donor age (yr)	25.6 ± 10.2	24.0 ± 6.5	0.98	0.93-1.04	0.549
Female donor, n (%)	33 (20.8)	6 (37.5)	0.44	0.15-1.29	0.133
Cold ischemic time (h)	7.72 ± 1.52	7.58 ± 1.11	0.94	0.66-1.33	0.711
Recipient age	43.7 ± 12.4	36.9 ± 12.0	0.96	0.92-0.99	0.028
Female recipient, n (%)	94 (59.8)	13 (72.2)	0.57	0.19-1.69	0.299
Donor CMV positive/recipient negative, n (%)	34 (21.4)	4 (25.0)	1.12	0.69-1.81	0.642
Donor/recipient sex mismatches, n (%)	88 (55.3)	11 (68.7)	1.78	0.59-5.35	0.308
HLA mismatches ≥ 4, n (%)	107 (67.3)	12 (75.0)	1.46	0.45-4.74	0.531
Prior transplant, n (%)	9 (5.7)	2 (12.5)	2.38	0.47-2.12	0.296
Campath-1H induction, n (%)	113 (71.1)	12 (75.0)	0.72	0.30-1.73	0.468
Liver-free graft, n (%)	92 (58.5)	15 (83.3)	3.53	1.08-12.7	0.031
Presence of spleen, n (%)	99 (63.1)	15 (83.3)	2.93	0.81-10.55	0.071
Anti-HLA antibodies
Positive CDC-XM, n (%)	30 (19.1)	14 (77.8)	21.17	5.76-77.81	< 0.0001
PRA I ≥ 10%, n (%)	53 (33.8)	18 (100)	33.36	4.32-257.52	< 0.0001
PRA II ≥ 10%, n (%)	32 (20.4)	14 (77.8)	13.67	4.21-44.36	< 0.0001
Presence of DSA, n (%)	37 (23.6)	18 (100)	55.14	7.09-428.38	< 0.0001

ABMR: Antibody-mediated rejection; CMV: Cytomegalovirus; CDC-XM: Complement-dependent lymphocytotoxic cross-match; PRA: Panel reactive antibody; DSA: Donor-specific antibody.