Stabilization of estimated glomerular filtration rate in kidney transplantation from deceased donors with acute kidney injuries

Table 1 Baseline characteristics

DDKT (n = 111)	SCD (32)	AKI (51)	ECD (28)	aP-value	bP-value
Recipients
Age year (mean ± SD)	42.7 ± 13.8	43.9 ± 12.0	43.1 ± 12.3	0.68	0.67
Male n (%)	19 (59.4)	35 (68.6)	16 (57.1)	0.48	0.55
Pre KT dialysis				1	1
Hemodialysis n (%)	26 (81.3)	42 (82.4)	23 (82.1)
Peritoneal dialysis n (%)	6 (18.8)	9 (17.7)	5 (17.9)
Comorbid n (%)
DM	2 (6.25)	8 (15.7)	3 (10.7)	0.3	0.48
HT	30 (93.8)	49 (96.1)	25 (89.3)	0.67	0.41
CAD	1 (3.1)	1 (1.9)	1 (3.6)	1	1
Cause of ESRD n (%)				0.91	0.73
Unknown (no biopsy)	23 (23.2)	33 (31.8)	18 (18.9)
Diabetic nephropathy	1 (0.9)	1 (1.3)	1 (0.8)
IgA nephropathy	1 (1.9)	2 (2.6)	3 (1.5)
Chronic glomerulonephritis	2 (0.9)	1 (1.3)	0 (0.8)
Blood group n (%)				0.14	0.38
A	4 (12.5)	13 (25.5)	7 (25.0)
B	13 (40.6)	13 (25.5)	7 (25.0)
AB	4 (12.5)	2 (3.9)	3 (10.7)
O	11 (34.4)	23 (45.1)	11 (39.3)
PRA - % median (range)	0 (0.85)	0 (0.0)	0 (0.0)	0.03	0.04
Second KT n (%)	2 (6.25)	3 (5.88)	1 (3.57)	1	1
Total HLA mismatch - (mean ± SD)	2.5 (1.2)	2.3 (1.1)	2.1 (1.1)	0.52	0.76
Donors
Age, year (mean ± SD)	33.9 ± 14.8	41.0 ± 12.0	61.2 ± 7.0	0.02	< 0.001
Male n (%)	24 (75.0)	44 (86.3)	17 (60.7)	0.25	0.04
Terminal serum creatinine (mg/dL) - median (range)	0.91 (0.73, 1.13)	2.22 (1.65, 3.20)	1.28 (0.99, 2.70)		< 0.001
Cold ischemic time, minute (mean ± SD)	1099 ± 291	1129 ± 294	1261 ± 242	0.65	0.5
Immunosuppressive drugs
Induction n (%)				0.11	0.19
No	16 (50.0)	16 (31.4)	9 (32.1)
ATG	5 (15.6)	11 (21.6)	11 (39.3)
Simulect	11 (34.4)	24 (47.1)	8 (28.6)
Maintenance n (%)				0.05	0.005
Tacrolimus/mycophenolate/prednisolone	16 (50.0)	27 (52.9)	13 (46.4)
Cyclosporin A/mycophenolate/prednisolone	15 (46.8)	16 (31.4)	5 (17.9)
Cyclosporin A/everolimus/prednisolone	0	7 (13.7)	8 (28.6)
Everolimus/mycophenolate/prednisolone	1 (3.1)	0	0

^aP-value compared between SCD and AKI;

^bP-value compared among SCD, AKI and ECD. DDKT: Deceased donor kidney transplant; SCD: Standard criteria donor; AKI: Acute kidney injury; ECD: Expanded criteria donor; KT: Kidney transplant; DM: Diabetes mellitus; HT: Hypertension; CAD: Cardiovascular disease; ESRD: End stage renal disease; HLA: Human leukocyte antigen; ATG: Antithymocyte globulin.