Quality of life 10 years after liver transplantation: The impact of graft histology

Table 2 Relationship between various parameters at 10-year post-liver transplantation and the incidence of hepatic steatosis on 10-year post-liver transplantation biopsy

	All subjects n = 72	No HS n = 48	HS n = 24	P1
Age at the time of survey	49 ± 15	47 ± 15	53 ± 12	NS
≥ 60 yr aged patients	28%	27%	29%	NS
Histological lesions
Steatosis	33%	-	100%
Macrovacuolar	28%	-	82%
Microvacuolar	1%	-	4%
Combined Mac-Mic	4%	-	14%
Initial and 10-yr maintained steatosis	8% (5 pat.)	0%	22%	0.002
Fibrosis (F1-F4)	53%	44%	71%	0.03
F1-F2	40%	35%	50%	NS
F3-F4	13%	8%	21%	NS
Combined fibrosis-steatosis	24%	0%	71%	< 0.0001
HCV(+) Fibrosis	44%	31%	71%	< 0.001
Bile duct lesions	36%	42%	25%	NS
Minimal change	23%	27%	17%	NS
Other potential steatosis factors
BMI (kg/m2)	22.4 ± 3.8	22.3 ± 3.9	22.6 ± 3.4	NS
Underweight (BMI ≤ 18.5)	13%	17%	4%
Normal weight (BMI = 18.5-24.9)	69%	65%	79%	NS
Overweight (BMI = 25-29.9)	14%	14%	13%
Obesity (BMI ≥ 30)	4%	4%	4%
HCV infection (de novo or recurrence)	57%	46%	79%	0.007
Arterial hypertension	53%	52%	54%	NS
Glycemia (mmol/L)	5.4 ± 2.0	5.1 ± 0.9	6.2 ± 3.2	NS
Diabeties mellitus	10%	8%	13%	NS
Maintenance immunosuppresssion
Cyclosporine A	96%	96%	96%	NS
Dosage (mg)	129.8 ± 58.1	135.0 ± 61.5	119.5 ± 50.4	NS
Prednisolone	93%	96%	88%	NS
Dosage (mg)	6.8 ± 3.1	6.9 ± 3.2	6.7 ± 2.9	NS
Azathioprine	43%	40%	50%	NS
Dosage (mg)	48.4 ± 15.7	51.3 ± 15.5	43.8 ± 15.5	NS

Continuous data are represented as mean ± SD, and categorical data as percentage.

¹Comparison between HS and No HS. HS: Hepatic steatosis; NS: Not significant; BMI: Body mass index.