Pharmacological Tie2 activation in kidney transplantation

Figure 5 Anti-inflammatory properties of vasculotide are not regulated on the transcriptional level. A-F: Mice were treated with vehicle (n = 3) or VT (n = 5) and underwent kidney transplantation. Transplanted kidneys were harvested on day 28 after transplantation. Explanted donor kidneys from day 0 served as control (n = 3). Expression levels of Intercellular adhesion molecule (ICAM-1), Vascular cell adhesion protein 1 (VCAM-1), Transforming growth factor β (TGFβ), collagen-1, collagen-3 and fibronectin in kidney homogenates were determined via RT-qPCR and analyzed using Mann-Whitney test (^aP < 0.05). VT: Vasculotide.