Pharmacological Tie2 activation in kidney transplantation

Figure 1 Vasculotide shows trends to improved kidney function and survival in an MHC-mismatched renal transplant model. C57Bl/6 donor mice received 500 ng VT or vehicle prior to surgery (-1 h). Balb/c recipients were injected with 500 ng VT i.p. or vehicle directly and on day 3 after kidney transplantation. A-C: Kidney function [serum creatinine, urea and lactate dehydrogenase (LDH) levels] was monitored on day 6, 14, 21 and 28 after transplantation in murine serum and analyzed with unpaired t test (day 6, n = 7-10); D: Kaplan-Meier survival after MHC-mismatch kidney transplantation (n = 11 per group). VT: Vasculotide.