Thromboelastographic reference ranges for a cirrhotic patient population undergoing liver transplantation

Table 2 Medians, means, ranges and reference ranges (2.5%-97.5% percentiles) for thromboelastographic variables obtained from the study population (261 cirrhotic patients) and from the 40 healthy patients

	r (min)	k (min)	α(degree)	MA (mm)	A(30) mm	A(60) mm	Ly30 (%)	Ly60 (%)
Cirrhotic patient population (n = 261)
Reference values	6.2-58.5	4.2-39.2	3.4-42.8	10.4-63.5	9.8-62	92-62	0-4	0-10
Mean ± SD	23.7 ± 12.5	14.9 ± 9.6	18.2 ± 10	35.3 ± 12.8	33.8 ± 12.8	32.3 ± 12.6	0.38 ± 1	2.28 ± 4.3
Median (range)	21.8 (2.2/75.4)	12.3 (1.6/68.1)	16.1 (1.7/67)	33.6 (2.2/71.9)	33 (2/86)	31 (2.2/85.5)	0.0 (0/11)	0.40 (0/44)
Healthy population (n = 40)
Reference values	11-26	3-14	15-46	43-64	41-64	42-63	0-4	0-5
Mean ± SD	19.6 ± 1.3	9.8 ± 0.9	20.6 ± 1.2	43.7 ± 2.9	43.2 ± 3.1	42.9 ± 0.8	0.8 ± 2.5	0.9 ± 2.1
Median (range)	17.8 (8-27)	7.2 (2-15)	18.1 (13-48)	41.5 (41-66)	42 (39-67)	41.7 (41-65)	0.7 (0-5)	0.76 (0-7)
1P	0.039	< 0.001	0.131	< 0.001	< 0.001	< 0 .001	0.06	0.038
Number of tests below normal	25 (9.5%)	2 (0.76%)	112 (42.9%)	200 (77%)	192 (74%)	207 (79%)	0	0
Number of tests above normal	84 (32%)	125 (47.9%)	2 (0.8%)	6 (2.3%)	5 (1.9%)	5 (1.9%)	2 (0.76%)	28 (10.7%)
Total number of tests outside the healthy population range	109 (41.5%)	127 (48.6%)	114 (43.7%)	206 (79.3%)	197 (74.4%)	212 (80.9%)	2 (0.76%)	28 (10.7%)

Number of test results outside the normal reference range proposed by the manufacturer. r: Time to initial fibrin formation; k: Time to clot formation; α: Alpha angle, rate of clot formation; MA: Maximum amplitude, absolute clot strength; A30: Maximum amplitude at 30 min after MA; Ly30: Fibrinolysis at 30 min after MA; Ly60: Fibrinolysis at 60 min after MA;

¹P value expresses the significant differences between the mean values obtained from the study population and from the healthy population.