BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Table 3 BK Nephropathy in heart transplant recipients

Ref.	Gender age	Renal function	Clinical associations
[11]	Male, 65 yr	ESRD Refused dialysis	No rejection episodes Urothelial transitional cell carcinoma causing bilateral hydronephrosis Death following perforated gastric ulcer
[84]	Female 59 yr	SCr 5.0 mg/dL Awaiting dialysis	Three severe rejection episodes early
[85]	Male 57 yr	ESRD On dialysis	Repeated rejection episodes
[86]	Male 26 yr	ESRD On dialysis	Multiple rejection episodes
[89]	Male 54 yr	ESRD Dialysis	Persistent rejection Death from arrhythmia
[90]	Male 12 yr	Last SCr 2.0 mg/dL	Cardiomyopathy from chemotherapy for Ewing’s sarcoma One rejection episode
[91]	Male 8 yr	ESRD On dialysis	8 rejection episodes in 1st heart transplant BK nephropathy after 2nd heart transplant
[93]	Female 9 yr	Peak SCr 1.9 mg/dL Last SCr 1.2 mg/dL	Rejection episodes not reported Reduction in BK viral load and improvement in renal function after leflunomide was started
[94]	Male 14 yr	ESRD Dialysis	Multiple rejection episodes Lymphoproliferative disorder in the 12th year BK nephropathy in the 16th year Death from multiple organ failure
[96]	Male 60 yr	ESRD On peritoneal dialysis	One rejection episode
[96]	Male 43 yr	eGFR 40 mL/min	Recurrent giant cell myocarditis in the transplanted heart One rejection episode

BK nephropathy was usually manifested several years post-heart transplantation. Ages reported in this Table are the calculated ages at the time of diagnosis of BK nephropathy. ESRD: End-stage renal disease; SCr: Serum creatinine; eFGR: Estimated glomerular filtration rate.