Liver transplantation for hepatocellular carcinoma in Ireland: Pre-operative alpha-fetoprotein predicts tumour recurrence in a 14-year single-centre national experience

Table 3 Univariate analysis of factors affecting recurrence free survival

	HR	CI	P-value
Male sex	0.681	0.156-2.971	0.609
Age	1.004	0.932-1.081	0.922
Aetiology of HCC
Alcoholic liver disease	0.775	0.155-3.887	0.757
Hepatitis C	3.272	0.798-13.417	0.100
Haemochromatosis	1.210	0.243-6.024	0.816
Other	0.027	0.000-16.500	0.271
Pre-operative α-fetoprotein > 100 ng/mL	6.668	1.661-26.768	0.007
Compliant with Milan criteria	1.354	0.271-6.761	0.712
Compliant with UCSF criteria	0.739	0.148-3.692	0.712
Largest lesion	1.326	0.976-1.801	0.071
Cirrhosis	23.025	0.000-327.873	0.604
Steatosis	0.045	0.000-546.731	0.664
Multifocal lesions	2.100	0.494-8.930	0.315
Micro-vascular invasion	1.560	0.376-6.463	0.540
Tumour differentiation
Well	0.249	0.046-1.340	0.105
Moderate	1.553	0.374-6.443	0.544
Poor	5.631	1.074-29.510	0.041
Incidental lesions	0.041	0.000-720.752	0.523

HCC: Hepatocellular carcinoma; UCSF: University of California San Francisco.