Long term outcomes of cardiac transplant for immunoglobulin light chain amyloidosis: The Mayo Clinic experience

Table 1 Demographics and orthotopic heart transplantation outcomes

AL-OHT	M/F	Age at OHT	List to OHT (d)	Year OHT	PO FU (yr)	Major outcomes
8	F	52	62	1997	16.5	Alive, doing well
22	F	53	1160	2011	3.9	Alive, PTLD in remission, VGPR on bortezomib
23	M	58	13	2011	3.1	Alive, doing well
1	M	45	86	1992	14.1	Died, progressive amyloid; renal transplantation 53 mo post OHT
17	F	51	94	2003	10.8	Died, renal failure, debility; hematologic relapse and renal amyloid
9	M	56	16	1998	8.6	Died, metastatic melanoma
2	M	44	126	1993	8.4	Died, PTLD, sepsis, progressive amyloidosis
12	F	57	44	1999	8.2	Died, cardiogenic shock secondary to cardiac amyloid, required dialysis for renal amyloid post ASHCT#2
3	M	56	14	1994	7.5	Died, progressive amyloid
14	M	33	30	1999	6.3	Died, cardiac allograft vasculopathy
16	F	53	33	2000	5.4	Died, progressive GI amyloid and stroke; renal transplant 23 mo post-op
7	M	61	415	1997	3.5	Died, progressive amyloid autonomic and peripheral neuropathy
18	M	56	33	2004	3.1	Died, complications of myelodysplastic syndrome
5	F	47	68	1995	2.6	Died, PTLD, progressive multifocal leukoencephalopathy
10	F	54	5	1998	2.2	Died, progressive amyloid
19	M	62	18	2005	2.1	Died, progressive amyloid peripheral neuropathy and GI involvement, recurrent pneumonia
4	M	49	86	1994	1.2	Died, progressive amyloid
21	F	51	29	2007	1.2	Died, progressive GI amyloid, right heart failure, renal failure, steroid myopathy vs amyloid neuropathy
13	F	51	103	1999	0.9	Died, sepsis, multiorgan failure after AHSCT
11	F	48	31	1999	0.7	Died, disseminated fungal infection after AHSCT
15	F	60	33	1999	0.6	Died, progressive amyloid peripheral and autonomic neuropathy
20	F	52	33	2006	0.6	Died, progressive amyloid and overwhelming infection
6	M	56	99	1996	0.04	Died, refractory rejection; had combined renal and cardiac transplant
Median (IQR)		53 (33, 62)	33 (29, 94)

The first three rows are alive. M: Male; F: Female; PO FU: Post-operative follow-up; PTLD: Post-transplant lymphoproliferative disorder; GI: Gastrointestinal; VGPR: Very good partial response; IQR: Interquartile range.