Impact of body mass index on outcomes of 48281 patients undergoing first time cadaveric liver transplantation

Table 8 Multivariate logistic analysis of in hospital, 90-d and 1-year mortality stratified by recipients’ body mass index at the time of liver transplantation

	Multivariate analysis: In hospital mortality		Multivariate analysis: 90-d mortality		Multivariate analysis: 1-yr mortality
Variable	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value	Odds ratio (95%CI)	P value
Recipient BMI
Normal weight	1		1		1
Underweight	1.359 (0.865-2.135)	0.184	1.737 (1.185-2.548)	0.005	1.505 (1.105-2.048)	0.009
Overweight	0.942 (0.798-1.112)	0.481	0.995 (0.856-1.157)	0.950	0.886 (0.792-0.992)	0.036
Obese class I	1.171 (0.974-1.408)	0.094	1.185 (1.000-1.430)	0.050	0.900 (0.792-1.028)	0.120
Obese class II	1.135 (0.889-1.450)	0.309	1.197 (0.959-1.495)	0.112	1.004 (0.846-1.193)	0.960
Obese class III	1.749 (1.276-2.397)	0.001	1.956 (1.473-2.597)	0.000	1.458 (1.154-1.842)	0.002
Donor BMI
Normal weight	1		1		1
Underweight	1.581 (1.214-2.060)	0.001	1.449 (1.131-1.857)	0.003	1.200 (0.978-1.472)	0.080
Overweight	1.025 (0.881-1.194)	0.746	1.008 (0.878-1.158)	0.907	1.025 (0.922-1.140)	0.647
Obese class I	0.983 (0.788-1.226)	0.878	1.016 (0.832-1.239)	0.879	1.061 (0.913-1.233)	0.437
Obese class II	1.217 (0.878-1.686)	0.239	1.189 (0.880-1.606)	0.259	1.223 (0.973-1.536)	0.996
Obese class III	1.013 (0.647-1.585)	0.955	0.952 (0.626-1.448)	0.817	0.999 (0.731-1.365)	0.996
Recipient age
18-45	1		1		1
46-55	1.305 (1.089-1.563)	0.004	1.324 (1.122-1.583)	0.001	1.302 (1.146-1.479)	0.000
56-65	1.563 (1.292-1.891)	0.000	1.719 (1.447-2.041)	0.000	1.650 (1.443-1.888)	0.000
66-75	2.251 (1.737-2.917)	0.000	2.451 (1.941-3.094)	0.000	2.570 (2.146-3.078)	0.000
≥ 76	5.081 (1.410-18.316)	0.013	6.345 (2.060-20.105)	0.001	2.694 (0.871-8.328)	0.344
Donor age
0-17	1		1		1
18-45	1.207 (0.961-1.516)	0.106	1.216 (0.988-1.496)	0.065	1.138 (0.968-1.337)	0.118
46-55	1.492 (1.154-1.929)	0.002	1.411 (1.117-1.784)	0.004	1.464 (1.221-1.755)	0.000
56-65	1.357 (1.027-1.793)	0.032	1.388 (1.079-1.785)	0.011	1.365 (1.123-1.660)	0.002
66-75	1.308 (0.929-1.843)	0.124	1.379 (1.014-1.875)	0.041	1.550 (1.230-1.954)	0.000
≥ 76	0.639 (0.291-1.403)	0.265	0.864 (0.456-1.638)	0.654	1.527 (1.034-2.253)	0.033
Recipient sex (male)	0.909 (0.787-1.050)	0.194	0.966 (0.847-1.102)	0.608	1.051 (0.948-1.164)	0.344
Donor sex (male)	1.017 (0.888-1.164)	0.807	1.009 (0.892-1.142)	0.888	0.993 (0.904-1.092)	0.888
Cold ischemia time (h)	1.033 (1.019-1.047)	0.000	1.021 (1.007-1.035)	0.003	1.024 (1.013-1.035)	0.000
Warm ischemia time (min)	1.008 (1.005-1.011)	0.000	1.007 (1.005-1.010)	0.000	1.006 (1.004-1.008)	0.000
Year of transplantation	0.987 (0.968-1.006)	0.182	0.970 (0.953-0.987)	0.000	1.003 (0.989-1.016)	0.686
Dialysis	2.922 (2.378-3.590)	0.000	2.824 (2.326-3.429)	0.000	2.436 (2.071-2.865)	0.000
Diabetes	1.165 (0.990-1.371)	0.065	1.149 (0.992-1.331)	0.063	1.226 (1.095-1.374)	0.000
COPD	1.276 (0.803-2.027)	0.303	1.155 (0.996-1.341)	0.057	1.233 (0.883-1.720)	0.219
Hypertension	0.957 (0.796-1.151)	0.642	0.959 (0.810-1.135)	0.624	1.027 (0.905-1.166)	0.680
Primary indication for transplant
HCV	1.369 (1.114-1.682)	0.003	1.215 (1.049-1.408)	0.009	0.980 (0.847-1.135)	0.791
Alcohol + HCV	1.307 (0.976-1.752)	0.073	1.038 (0.808-1.332)	0.772	0.961 (0.788-1.173)	0.698
HCV + Other viral hepatitis	1.307 (0.976-1.752)	0.073	0.895 (0.509-1.575)	0.701	0.876 (0.564-1.362)	0.558
Other	0.730 (0.549-0.970)	0.030	0.693 (0.544-0.883)	0.003	0.843 (0.677-1.050)	0.128
Alcohol	1.380 (1.095-1.740)	0.006	1.172 (0.988-1.391)	0.068	1.366 (1.153-1.618)	0.000
HBV	1.230 (0.871-1.737)	0.239	1.263 (0.912-1.747)	0.159	1.326 (1.023-1.719)	0.033
PSC	1.749 (1.229-2.489)	0.002	1.608 (1.190-2.172)	0.002	1.777 (1.377-2.293)	0.000
PBC	1.989 (1.394-2.837)	0.000	1.834 (1.352-2.487)	0.000	1.754 (1.365-2.252)	0.000
NASH	1.564 (0.899-2.722)	0.113	1.043 (0.660-1.649)	0.857	1.298 (0.902-1.869)	0.160
Autoimmune	1.179 (0.825-1.686)	0.365	0.879 (0.648-1.191)	0.405	1.027 (0.794-1.329)	0.840
Acute liver failure	0.839 (0.462-1.522)	0.839	0.797 (0.450-1.410)	0.435	1.183 (0.712-1.964)	0.517
Congenital or metabolic disease	1.139 (0.832-1.522)	0.563	1.094 (0.821-1.458)	0.540	1.162 (0.919-1.469)	0.211

HCV: Hepatitis C virus; HBV: Hepatitis B virus; PSC: Primary sclerosing cholangitis; NASH: Non-alcoholic steatohepatitis; COPD: Chronic obstructive pulmonary disease; PBC: Primary biliary cirrhosis.