Survival of encapsulated islets: More than a membrane story

Figure 10 Predictions of the mathematical model for PO₂ levels. The parameters of the model were set as follow: Islet dose in each of the 2 islet modules, 60000 IEQ; surface density of 3600 IEQ/cm², and OCR of 3.6 pmoles/IEQ/min. A: PO₂ profile at the central cavity (green line) and at the “reduced pressure chamber” (red line) of a porcine-type β-Air device. The central cavity was refueled with 95% oxygen/5% CO₂ at 1.4 atm (1011 Torr); B: PO₂ across a section of an islet module of a β-Air device refueled with 95% oxygen at either 1.2 (purple line) or 1.4 (red line) atm. The red dashed lines represent distances of 50 and 450 μm from the chamber-islet module boundary.