Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation

Table 2 Effect of cyclosporin A or castanospermine or both upon cardiac allograft survival

Mean survival for each dose group of cyclosporin A by castanospermine1,2
	Castanospermine dose3,4
		0	50	100	150	200	300
Cyclosporin A dose4	0.0	7.5	9.7	13.1	31.7	45	75.7
	0.5	7.4		38.9		73.8
	2.0	8.4	13.2	75.5		99.3
	3.0	10.7	30.7	100
	4.0	85.2

¹PVG donor into DA recipient;

²The mean survival of the syngeneic control (DA into DA) was 100 d;

³Survival times are truncated at 100 d;

⁴Drug doses are given in mg/kg per day body weight.