Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation

Table 1 Effect of cyclosporin A or castanospermine or both upon cardiac allograft survival

No. of subjects and (number alive at 100 d) for each dose group of cyclosporin A by castanospermine1,2
	Castanospermine dose3,4
		0	50	100	150	200	300
Cyclosporin A dose4	0.0	14 (0)	7 (0)	7 (0)	7 (1)	6 (1)	6 (4)
	0.5	7 (0)		7 (2)		6 (4)
	2.0	10 (0)	7 (0)	11 (7)		6 (5)
	3.0	6 (0)	6 (1)	6 (6)
	4.0	6 (5)

¹PVG donor into DA recipient;

²The syngeneic control, DA into DA, was 4 (4);

³Survival times are truncated at 100 d;

⁴Drug doses are given in mg/kg per day body weight.