Combining cytochrome P-450 3A4 modulators and cyclosporine or everolimus in transplantation is successful

Table 2 Follow up clinical findings and complications n (%)

	Everolimus (n = 59)	Azathioprine/MMF (n = 114)	P value
Surgical complication	11 (19)	25 (22)	0.61
Vascular complication	2 (3)	10 (9)	0.22
First year acute rejection episode	6 (10)	25 (22)	0.06
Acute rejection episode during entire follow up period	12 (20)	41 (36)	0.04
Cyclosporine toxicity	8 (14)	22 (19)	0.35
New onset diabetes after transplant	3 (5)	8 (7)	0.75
CMV disease	0 (0)	6 (5.3)	0.10
BK virus nephropathy	1 (2)	5 (4)	0.67
New onset neoplasia	2 (3)	6 (5)	0.72
Post-transplant Lymphoproliferative disease	1 (2)	2 (2)	0.98
Hospitalizations/yr	0.50 ± 0.72	0.62 ± 0.78	0.32
Leucopenia	12 (20)	58 (51)	< 0.01
Thrombocytopenia	29 (49)	73 (64)	0.06
Pneumonia	6 (10)	25 (22)	0.06
Urinary tract infection	27 (46)	46 (40)	0.49

MMF: Mycophenolate mofetyl; CMV: Cytomegalovirus.