Use of genetically-engineered pig donors in islet transplantation

doi:10.5500/wjt.v5.i4.243

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Dec 24, 2015; 5(4): 243-250
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.243

Table 2 Several genetic manipulations of pigs currently available with potential use for clinical islet transplantation

GE manipulation	Target	Expression	Ref.
GTKO	Humoral response	Ubiquitous	[15,16,46]
NeuGcKO	Humoral response	Ubiquitous
B4GalNT2KO	Humoral response	Ubiquitous
HumanCD46	Complement regulation	Ubiquitous	[12,16]
HumanCD55	Complement regulation	Ubiquitous	[46]
HumanCD59	Complement regulation	Ubiquitous	[46]
HumanTFPI	Anticoagulation	Beta cells	[16]
HumanCD39	Anticoagulation	Beta cells
Human thrombomodulin	Anticoagulation
Human A20 (tumor necrosis factor-alpha-induced protein 3)	Anticoagulation/anti-inflammatory/anti-apoptotic gene expression
Human heme oxygenase-1	Anticoagulation/anti-inflammatory/anti-apoptotic gene expression
Human signal regulatory protein α	Anticoagulation/anti-inflammatory/anti-apoptotic gene expression
CTLA4-Ig (CD152)	Cellular response	Beta cells	[16]
HLA-E/human b2-microglobulin	Cellular response
LEA29Y	Cellular response
PERV siRNA	PERV activation

GE: Genetically-engineered; GTKO: Alpha1,3-galactosyl transferase-gene knockout; TFPI: Tissue factor pathway inhibitor; PERV: Porcine endogenous retroviruse.

Citation: Bottino R, Trucco M. Use of genetically-engineered pig donors in islet transplantation. World J Transplant 2015; 5(4): 243-250
URL: https://www.wjgnet.com/2220-3230/full/v5/i4/243.htm
DOI: https://dx.doi.org/10.5500/wjt.v5.i4.243