Use of genetically-engineered pig donors in islet transplantation

doi:10.5500/wjt.v5.i4.243

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Dec 24, 2015; 5(4): 243-250
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.243

Table 1 Genetically-engineered pig islets to diabetic NHP models

GE manipulation	Pig age	Survival (d)	Immunosuppression	Ref.
GTKO	Neonatal	249	Anti-CD154 + anti-LFA1 + CTLA-4-Ig + MMF	[15]
CD46	Adult	396	Anti-CD154 + ATG + MMF	[12]
GTKO/CD46/TFPI/CTLA4-Ig	Adult	365	Anti-CD154 + ATG + MMF	[16]
GTKO/CD55/CD59/HT	Neonatal	30	ATG + MMF + Tacrolimus	[46]

GE: Genetically-engineered; GTKO: Alpha1,3-galactosyl transferase-gene knockout; MMF: Mycophenolate mofetil; TFPI: Tissue factor pathway inhibitor; HT: H-transferase; ATG: Antithymocyte globulin.

Citation: Bottino R, Trucco M. Use of genetically-engineered pig donors in islet transplantation. World J Transplant 2015; 5(4): 243-250
URL: https://www.wjgnet.com/2220-3230/full/v5/i4/243.htm
DOI: https://dx.doi.org/10.5500/wjt.v5.i4.243