Update on ischemia-reperfusion injury in kidney transplantation: Pathogenesis and treatment

Figure 3 Schematic view of innate inflammatory response. PAMPs: Pathogen associated molecular patterns; DAMPs: Danger associated molecular patterns; TLRs: Toll-like receptors; TRAF6: TNF receptor-associated factor 6; MyD88: Myeloid differentiation primary response 88; TIRAP: Toll-interleukin 1 receptor (TIR) domain containing adaptor protein; TRAM: TRIF-related adaptor molecule; TRIF: TIR domain containing adaptor protein inducing interferon β; IRAK1: Interleukin 1- receptor-associated kinase 1; TBK1: TANK binding kinase 1; IKK: Inhibitor of nuclear factor kappa-B kinase; NFκB: Nuclear factor kappa B; MAP3: MAP3 kinase; IFR3: Interferon regulatory factor 3.