Underestimation of chronic renal dysfunction after liver transplantation: ICEBERG study

Table 4 Predictive factors associated with developing chronic renal dysfunction in liver transplant recipients

Variables	HR (95%CI)	P-value
Three months post-transplant eGFR (< 60 vs≥ 60 mL/min per 1.73 m2)	4.76 (2.78-8.33)	< 0.0001
CNI treatment at discharge (CNI vs non-CNI)	2.31 (1.05-5.07)	0.0371
Recipient gender (male vs female)	1.98 (1.09-3.60)	0.026
Year of transplantation ( ≤ 1999 vs > 1999)	1.95 (1.08-3.54)	0.0279

Other analyzed but non-significant variables were: donor gender (male or female), reason for transplantation (hepatitis C virus-related or not), antibody induction therapy at transplantation (yes or no), biopsy-confirmed graft rejection (yes or no), post-transplant diabetes mellitus (yes or no), post-transplant hypertension (yes or no), and pre-transplant eGFR (< 60 or ≥ 60 mL/min per 1.73 m²). eGFR: Estimated glomerular filtration rate; CNI: Calcineurin inhibitors.