Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients

doi:10.5500/wjt.v4.i2.133

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 24, 2014; 4(2): 133-140
Published online Jun 24, 2014. doi: 10.5500/wjt.v4.i2.133

Table 3 Serum levels of liver fibrosis mediators

	Everolimus patients(n = 30)	CNI patients(n = 30)	P value
VCAM (ng/mL)	68.25 (25.98-135.17)	58.88 (35.30-115.52)	0.668
PIIINP (ng/mL)	172.4 (119.75-1195.90)	879.40 (140.10-1555.15)	0.193
IP-10 (pg/mL)	86.01 (51.10-210.91)	79.61 (59.2-172.64)	0.669
HGF (pg/mL)	225.17 (163.30-320.17)	205.53 (152.59-297.86)	0.363
Angiopoietin (ng/mL)	26.97 (19.58-32.25)	30.108 (24.60-38.8)	0.122
TNF-α (ng/mL)	41.12 (38.35-44.8)	42.70 (40.20-45.07)	0.435
IL-10 (pg/mL)	8.52 (6.07-9.23)	8.66 (6.95-9.40)	0.856
TGF-β (ng/mL)	12.7 (3.7-133.6)	152.5 (14.4-333.2)	0.009
HA (ng/mL)	702.89 (329.4-838.2)	1513.6 (691.9-1951.4)	0.001
PDGF (ng/mL)	1.5630 (1.4663-1.6369)	1.5630 (1.4616-1.6369)	0.720

Variables are expressed as medians and interquartillic range. VCAM: Vascular cell adhesion molecule; PIIINP: Amino-terminal propeptide of type III procollagen; IP10: Interferon-inducible protein 10 calcineurin inhibitor; TNF-α: Transforming necrosis factor alpha; TGF: Tissue growth factor; HGF: Hepatocyte growth factor; HA: Hyaluronic acid; PDGF: Platelet derived growth factor.

Citation: Fernández-Yunquera A, Ripoll C, Bañares R, Puerto M, Rincón D, Yepes I, Catalina V, Salcedo M. Everolimus immunosuppression reduces the serum expression of fibrosis markers in liver transplant recipients. World J Transplant 2014; 4(2): 133-140
URL: https://www.wjgnet.com/2220-3230/full/v4/i2/133.htm
DOI: https://dx.doi.org/10.5500/wjt.v4.i2.133