Multiple indications for everolimus after liver transplantation in current clinical practice

Table 1 Characteristics of recipients, donors, surgery and post-transplant evolution in 74 patients receiving everolimus n (%)

Recipient	Mean age (yr)	55.5 ± 9 r (25-69)
	Patients > 65 yr	10 (13.5)
	Male/female	55 (74.3)/19 (25.7)
	Diagnosis
	HCC with cirrhosis	35 (47.2)
	Alcoholic cirrhosis	18 (24.3)
	HCV cirrhosis	16 (21.6)
	Cholostatic cirrhosis	3 (4.1)
	Liver insufficiency	2 (2.8)
	HCV - HBV	40 (54)-3 (4)
	ETOH	38 (51.4)
	HIV	4 (5.4)
	Child-Pugh A/B/C (%)	35-30-35
	UNOS (home/Hosp/ICU (%)	90.5-6.8-2.7
	Pre-LT associated disease
	Renal insufficiency	11 (14.9)
	Diabetes mellitus	18 (24.3)
	Arterial hypertension	14 (18.9)
	Cardiopathy	3 (4.1%)
	Previous surgery	15 (20.3)
Donor	Mean age (yr)	48 ± 19 r (14-81)
	Patients > 70 yr	14 (19)
	Male/female (%)	49 (66)/25 (34)
	Graft steatosis > 20%	11 (15)
	Death (CET, CVA, Other) (%)	43-43-14
Surgery	E-E/E-E + Kehr/C-Y (%)	84-8-8
	Previous portal thrombosis	10 (13.6)
	Median RBC units	4 (r: 0-40)
	Cold ischaemia time (min)	378 ± 97
Post-transplant evolution	Ischaemia-reperfusion injury	14 (19)
	(ALT > 1000 IU, Quick < 60%)
	Biliary complication	7 (9.5)
	Postoperative arterial complication	2 (2.7)
Median time from event to conversion		1 mo (r: 0.1-19)
Median time from LT to conversion		6 mo (r: 0.1-192)
Early/late conversion	< 1 yr/≥ 1 yr	42 (56.8)/32 (43.2)
Mean follow-up post-conversion		22 ± 19 mo (r: 0.5-74)
Median follow-up post-conversion		17.5 mo

HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; HBV: Hepatitis B virus; ETOH: Cirrhosis due to alcohol; HIV: Human immunodeficiency virus; UNOS: United Network for Organ Sharing classification; ICU: Intensive care unit; LT: Liver transplantation; CET: Cranioencephalic trauma; CVA: Cerebrovascular accident; E-E: End-to-end choledoco-choledostomy; E-E + K: End-to-end choledoco-choledostomy + kehr; C-Y: Choledoco-jejunostomy; RBC: Red blood cells; IU: International units; r: Range.