Review
Copyright ©2013 Baishideng Publishing Group Co.
World J Transplant. Dec 24, 2013; 3(4): 68-77
Published online Dec 24, 2013. doi: 10.5500/wjt.v3.i4.68
Table 2 Non-Food and Drug Administration approved/investigational agents and their mechanism
Drug nameMechanism of action
Induction
Efalizumab1Humanized antibody, CD11a/LFA-1
Alefacept1Costimulation inhibitor, CD2 LFA3
Maintenance
Voclosporin, ISA247Calcineurin inhibitor
Sotrastaurin, AEB0711Protein kinase C inhibitor
Tofacitinib, CP-6905501JAK 3 inhibitor
ASKP1240Anti-CD40 monoclonal antibody
Treatment of Antibody Medicated Rejection
BortezomibProteasome inhibitor
EculizumabMonoclonal antibody, C5 complement protein