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©2013 Baishideng Publishing Group Co.
World J Transplant. Jun 24, 2013; 3(2): 7-25
Published online Jun 24, 2013. doi: 10.5500/wjt.v3.i2.7
Published online Jun 24, 2013. doi: 10.5500/wjt.v3.i2.7
Table 2 Withdrawal/conversion trials
| Study (yr) | Drugs | F-up(mo) | Patient survival | Graft survival | Biopsyproven acuterejection | Glomerular filtration rate (mL/min) | ||||
| SRL/EVR | CNI | SRL/ EVR | CNI | SRL/EVR | CNI | SRL/EVR | CNI | |||
| RMR (2004) | SRL (SRL+CsA) | 48 | 95.3% | 92.1% | 91.5% | 84.2% | 10.2 | 6.5 | 58.3 | 43.8 |
| Spare the Nephron (2011) | SRL/CNI | 24 | 100% | 97.5% | 100% | 98.7% | 9.5 | 11.3 | 59.5 | 58.8 |
| CONCEPT (2009) | SRL/CsA | 12 | 100% | 100% | 100% | 99.0% | 16.8 | 8.2 | 69.6 | 64.8 |
| SMART (2010) | SRL/CsA | 12 | 99.0% | 99% | 99.0% | 97.0% | 17.4 | 15.5 | 64.5 | 53.4 |
| ZEUS (2012) | EVR/CsA | 36 | 98.1% | 97.9% | 98.7% | 98.6% | 13.0 | 4.8 | 67.9 | 60.6 |
| HERAKLES (2012) | EVR/CsA | 12 | 99.4% | 98.8% | 99.4% | 99.4% | 10.0 | 8.4 | 68.6 | 63.0 |
- Citation: Salvadori M, Bertoni E. Is it time to give up with calcineurin inhibitors in kidney transplantation? World J Transplant 2013; 3(2): 7-25
- URL: https://www.wjgnet.com/2220-3230/full/v3/i2/7.htm
- DOI: https://dx.doi.org/10.5500/wjt.v3.i2.7