Polyomavirus-associated nephropathy

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Dec 24, 2012 (publication date) through Nov 18, 2024

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Dec 24, 2012; 2(6): 84-94
Published online Dec 24, 2012. doi: 10.5500/wjt.v2.i6.84

Table 2 Determinants in the development of polyomavirus-associated nephropathy

Determinants
Patient-related	Age > 50 yr
	Male gender
	Comorbidities (diabetes mellitus)
	Negative serostatus before transplantation
Organ-related	Degree of HLA mismatching
	Prior rejection episodes
	Renal injury
	Latent infection load
Viral-related	NCCR rearrangements
	Genotype
	Viral fitness
Immunity-related	Intense triple immunosuppression (calcineurin-inhibitor, antiproliferative agent, steroid)
	Rejection and anti-rejection treatment (anti-lymphocyte preparations, iv steroid boluses)
	Positive serostatus of donor
	Low number of BKV-specific T-cells

NCCR: Noncoding control region; BKV: BK virus.

Citation: Costa C, Cavallo R. Polyomavirus-associated nephropathy. World J Transplant 2012; 2(6): 84-94
URL: https://www.wjgnet.com/2220-3230/full/v2/i6/84.htm
DOI: https://dx.doi.org/10.5500/wjt.v2.i6.84