Extended travel for donor organs: Is cold static storage still relevant

Table 6 Matched transplant outcomes, n (%)

Variable	Overall (n = 416)	Cold static storage (n = 312)	Ex vivo lung perfusion (n = 104)	P value
Center volume	32 (14, 56)	32 (14, 56)	32 (14, 56)	0.761
Center volume yearly	2.1 (0.9, 3.7)	2.1 (0.9, 3.7)	2.1 (0.9, 3.7)	0.761
Perfused by
Organ perfusion organization		0 (N/A)	2 (1.9)
Transplant program		0 (N/A)	61 (59.2)
External perfusion center		0 (N/A)	40 (38.8)
Perfusion time			294.5 (217, 507)
Warm ischemic time	24 (19.7, 28.5)	23 (18, 26)	25 (20, 30)	0.129
Type of lung transplant				0.009
Bilateral	319 (76.7)	228 (73.1)	91 (87.5)
Right single	40 (9.6)	36 (11.5)	4 (3.8)
Left single	57 (13.7)	48 (15.4)	9 (8.7)
Distance traveled (nautical miles)	894 (826, 1006.2)	900 (825.5, 1000.8)	892 (826.8, 1062.8)	0.862
Ischemic time (hours)	7.7 (6.4, 10.3)	7.1 (6.1, 8.2)	13.6 (10.8, 16.2)	< 0.001
Length of stay (days)	19 (13, 37)	19 (13, 35.8)	22 (14, 48.5)	0.278
In-hospital mortality	31 (7.7)	22 (7.3)	9 (8.7)	0.798
Postop dialysis	38 (9.2)	23 (7.4)	15 (14.6)	0.046
Postop stroke	18 (4.3)	14 (4.5)	4 (3.8)	0.99
Airway dehiscence	10 (2.4)	10 (3.2)	0 (0)	0.139
Post-operative extracorporeal membrane oxygenation	43 (10.4)	26 (8.3)	17 (16.5)	0.03
Post-operative ventilator				0.02
None	6 (1.5)	4 (1.3)	2 (2)
< 2 days	213 (51.8)	173 (56)	40 (39.2)
2-5 days	87 (21.2)	63 (20.4)	24 (23.5)
5+ days	105 (25.5)	69 (22.3)	36 (35.3)
Primary graft dysfunction grade 3	59 (14.2)	45 (14.4)	14 (13.5)	0.935
Acute rejection (hospitalization)				0.052
Yes and treated with immunosuppressant	26 (6.2)	15 (4.8)	11 (10.6)
Yes and not treated with Immunosuppressant	4 (1)	2 (0.6)	2 (1.9)
No	386 (92.8)	295 (94.6)	91 (87.5)
Treated rejection (1st year)	44 (17.7)	23 (12.7)	21 (30.9)	0.002
Cause of death				0.625
Graft failure	17 (18.1)	14 (18.7)	3 (15.8)
Malignancy	1 (1.1)	1 (1.3)	0 (0)
Cardio/cerebrovascular	13 (13.8)	9 (12)	4 (21.1)
Pulmonary	16 (17)	12 (16)	4 (21.1)
Infection	31 (33)	24 (32)	7 (36.8)
Other	16 (17)	15 (20)	1 (5.3)
Year of transplant
2018	44 (10.6)	31 (9.9)	13 (12.5)
2019	69 (16.6)	49 (15.7)	20 (19.2)
2020	88 (21.2)	71 (22.8)	17 (16.3)
2021	99 (23.8)	70 (22.4)	29 (27.9)
2022	109 (26.2)	87 (27.9)	22 (21.2)
2023	7 (1.7)	4 (1.3)	3 (2.9)

Variables are either presented as median, interquartile range or n, percentage when appropriate. N/A: Not applicable.