Extended travel for donor organs: Is cold static storage still relevant

Table 3 Transplant outcomes, n (%)

Variable	Overall (n = 897)	Cold static storage (n = 792)	Ex vivo lung perfusion (n = 105)	P value
Center volume	30 (12, 56)	30 (12, 56)	32 (14, 56)	0.526
Center volume yearly	2 (0.8, 3.7)	2 (0.8, 3.7)	2.1 (0.9, 3.7)	0.526
Perfused by
Organ perfusion organization			2 (1.9)
Transplant program			61 (58.7)
External perfusion center			41 (39.4)
Perfusion time			296 (218, 496)
Warm ischemic time	24 (19.3, 28)	24 (19, 26.8)	25.5 (20, 30.3)	0.113
Type of lung transplant				0.001
Bilateral	653 (72.8)	561 (70.8)	92 (87.6)
Right single	100 (11.1)	96 (12.1)	4 (3.8)
Left single	144 (16.1)	135 (17)	9 (8.6)
Distance traveled (nautical miles)	898 (824, 1006)	900 (824, 1006)	892 (826, 1058)	0.96
Ischemic time (hours)	7.3 (6.2, 8.8)	7.1 (6.1, 8.2)	13.5 (10.8, 16.2)	< 0.001
Length of stay (days)	20 (13, 38)	20 (13, 37)	22 (14, 48.5)	0.553
In-hospital mortality	59 (7.2)	50 (7)	9 (8.7)	0.668
Postop dialysis	81 (9.6)	65 (8.8)	16 (15.4)	0.049
Postop stroke	34 (4)	30 (4)	4 (3.8)	0.999
Airway dehiscence	16 (1.9)	16 (2.2)	0 (0)	0.254
Post-operative extracorporeal membrane oxygenation	97 (11.5)	79 (10.7)	18 (17.3)	0.068
Post-operative ventilator				0.011
None	7 (0.8)	5 (0.7)	2 (1.9)
< 2 days	445 (53.1)	405 (55.1)	40 (38.8)
2-5 days	167 (19.9)	143 (19.5)	24 (23.3)
5+ days	219 (26.1)	182 (24.8)	37 (35.9)
Primary graft dysfunction grade 3	123 (13.7)	108 (13.6)	15 (14.3)	0.975
Acute rejection (hospitalization)				0.014
Yes and treated with immunosuppressant	49 (5.8)	38 (5.1)	11 (10.5)
Yes and not treated with Immunosuppressant	5 (0.6)	3 (0.4)	2 (1.9)
No	792 (93.6)	700 (94.5)	92 (87.6)
Treated rejection (1st year)	84 (16.2)	63 (13.9)	21 (30.9)	0.001
Cause of death				0.827
Graft failure	35 (17.9)	32 (18.3)	3 (15)
Malignancy	4 (2.1)	4 (2.3)	0 (0)
Cardio/cerebrovascular	29 (14.9)	25 (14.3)	4 (20)
Pulmonary	33 (16.9)	29 (16.6)	4 (20)
Infection	58 (29.7)	51 (29.1)	7 (35)
Other	36 (18.5)	34 (19.4)	2 (10)
Year of transplant
2018	96 (10.7)	83 (10.5)	13 (12.4)
2019	142 (15.8)	122 (15.4)	20 (19)
2020	170 (19)	153 (19.3)	17 (16.2)
2021	209 (23.3)	180 (22.7)	29 (27.6)
2022	220 (24.5)	197 (24.9)	23 (21.9)
2023	60 (6.7)	57 (7.2)	3 (2.9)

Variables are either presented as median, interquartile range or n, percentage when appropriate.