Increased reflux burden on pre-transplant reflux testing independently predicts significant pulmonary function decline after lung transplantation

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Sep 18, 2025 (publication date) through Apr 18, 2025

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Transplant. Sep 18, 2025; 15(3): 100111
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.100111

Table 3 Multichannel intraluminal impedance and pH measures and time to forced expiratory volume in 1 decline

Characteristics	Univariate hazard ratio for pulmonary function decline (95%CI)	P value	Multivariate analyses (separate models controlling for age, sex, BMI)	P value
Elevated AET (> 4.2%)	3.49 (1.15-10.6)	0.03	3.37 (1.08-10.6)	0.04
Elevated total reflux episodes (> 73)	1.09 (0.34-3.48)	0.89	1.45 (0.40-5.27)	0.57
Elevated proximal acid episodes (> 28)	3.34 (1.02-11.0)	0.04	3.29 (0.90-12.1)	0.07

CI: Confidence interval; BMI: Body mass index; AET: Acid exposure time.

Citation: Lo WK, Fernandez AM, Feldman N, Sharma N, Goldberg HJ, Chan WW. Increased reflux burden on pre-transplant reflux testing independently predicts significant pulmonary function decline after lung transplantation. World J Transplant 2025; 15(3): 100111
URL: https://www.wjgnet.com/2220-3230/full/v15/i3/100111.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i3.100111