Haemoadsorption cartridge connected to the machine perfusion for donation after circulatory death porcine liver marginal grafts

Figure 3 Cytokines measurements from perfusates of the livers during hypothermic machine perfusion and hypothermic machine perfusion-Persorb treatments. Baseline levels of cytokines were similar between groups at liver biopsies were analyzed, thereby retrieved at the slaughterhouse immediately after the donor warm ischemia time. Significantly changes were observed for interleukin (IL)-1β at start. Levels of monocyte chemotactic protein-1, IL-6 and IL-1β and IL-8 remained significantly higher in the hypothermic machine perfusion (HMP) group compared to HMP-Sorb group (^aP < 0.05). The following cytokines were presented in abbreviations in the graphs: (1) IL-β; (2) Tumor necrosis factor-alpha; and (3) Monocyte chemotactic protein-1. Data are presented as mean ± SD. IL: Interleukin; MCP-1: Monocyte chemotactic protein-1; Sorb: Hypothermic machine perfusion with PerSorb; TNF-α: Tumor necrosis factor-alpha; T-1: Liver biopsies were analyzed, thereby retrieved at the slaughterhouse immediately after the donor warm ischemia time; Tend: At the end; T0: Start; T2: After two hours.