Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined

doi:10.5500/wjt.v15.i2.99170

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Jun 18, 2025 (publication date) through Feb 21, 2025

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 18, 2025; 15(2): 99170
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.99170

Table 4 Comparative analysis of L-GrAFT₇, recipient and normothermic machine perfusion pump parameters across machine perfusion time groups, n (%)

Recipient and graft descriptors	< 8 hours (n = 12)	8-16 hours (n = 27)	16-24 hours (n = 10)	P value
LOS (days)	10 (6-42)	9 (6-24)	8 (6-38)	0.363
ICU LOS (days)	3.92 (2.21-25.47)	3.16 (0.16-9.15)	3.12 (0.71-8.08)	0.428
ICU readmission	0 (0)	2 (7.4)	4 (40)	0.009
Age (years)	62.5 (48-72)	57 (33-68)	59 (43-70)	0.227
Transplant model for end-stage liver disease	26.5 (13-39)	25 (7-34)	24 (7-30)	0.890
Machine perfusion time (minutes)	337 (223-458)	722 (510-920)	1154 (995-1446)	0.001
L-GrAFT₇	3.9 (1.9-20.1)	5.5 (2-42.8)	4.8 (2.1-44.0)	0.312
Early allograft dysfunction	1 (8.33)	2 (7.41)	1 (8.33)	0.992
Donor risk index	1.62 (1.38-2.03)	1.63 (1.28-2.74)	1.71 (1.34-2.49)	0.670
Cold ischemia time (minutes)	135 (80-219)	153.5 (45-210)	140.5 (94-241)	0.719
Warm ischemia time (minutes)	28 (18-110)	29 (19-132)	29.5 (8-110)	0.970

All values except early allograft dysfunction (EAD) displayed as median (range). EAD displayed as count (percentage). LOS: Length of stay; ICU: Intensive care unit.

Citation: Archie WH, Baimas-George M, Haynes N, Kundu S, Peterson K, Wehrle CJ, Huckleberry D, Eskind L, Levi D, Soto JR, Denny R, Casingal V, Cochran A, Rein EH, Vrochides D. Upper limit of normothermic machine preservation of liver grafts from donation after circulatory death yet to be defined. World J Transplant 2025; 15(2): 99170
URL: https://www.wjgnet.com/2220-3230/full/v15/i2/99170.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i2.99170