Prevalence and risk of progression of pancreatic cystic lesions in immunosuppressed patients: A systematic review and meta-analysis

Table 1 Characteristics of the study population used for the meta-analysis on cyst progression

Agarwal et al[9], 2016
Patients n (IS/ control)	26/26
Mean Age in years (IS/control)	60/63
Reason for IS	Solid organ transplantation (35.9%), autoimmune disorders (33.3%), inflammatory bowel disease (15.4%), other conditions (15.4%)
Follow up in months (IS/control)	24.3/21.5
Type of included cysts	IPMN, MCN
Primary outcome	1. Obstructive jaundice in a patient with cystic lesion of the head of the pancreas
	2. Enhancing solid components within the cyst
	3. Main pancreatic duct diameter measuring 10 mm or larger
	4. Cyst progression to 30 mm or larger
	5. Development of thickened/enhancing cyst walls
	6. Increase of main pancreatic duct size 5-9 mm
	7. Development of non-enhancing mural nodules
	8. Abrupt change in caliber of the pancreatic duct with distal pancreatic atrophy
Dorfman et al[8], 2016
Patients n (IS/control)	16/131
Mean age in years (IS/control)	61/70
Type of included cysts	IPMN
Reason for IS	Liver transplantation
Follow up in months (IS/control)	31/31
Primary outcome	Development of:
	1. Presence of mural nodules
	2.Cyst size of ≥ 30 mm
	3. Thickened cyst walls
	4. Pancreatic duct diameter of 5 to 9 mm
	5. Abrupt change in the duct caliber with distal pancreatic atrophy and lymphadenopathy
Gill et al[19], 2009
Patients n (IS/control)	33/57
Mean age in years (IS/control)	63/68
Reason for IS	Solid organ transplantation [liver (81.8%), kidney (15.2%), heart (3.0%)]
Follow up in months (IS/control)	29/28
Type of included cysts	IPMN
Primary outcome	Consensus indication for resection (i.e., cyst-related symptoms, cyst size > 30 mm, mural nodules, positive cytology)
Lennon et al[10], 2014
Patients n (IS/control)	23/274
Mean age in years (IS/control)	56.8/63.7
Reason for IS	Liver transplantation
Follow up in months (IS/control)	53.7/24
Type of included cysts	IPMN
Primary outcome	1. Jaundice secondary to the pancreatic cyst
	2. Mural nodule or solid component within the cyst
	3. Cytology suspicious or diagnostic for malignancy
	4. Cyst diameter 3 cm
	5. Main pancreatic duct involvement (pancreatic duct diameter 5 mm)

IS: Immunosuppression; IPMN: Intraductal papillary mucinous neoplasm; MCN: Mucinous cystic neoplasm.