Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for CYP3A5-polymorphism in kidney-transplant recipients

Table 1 Characteristics of patients (n = 86), mean ± SD

Characteristics		Values, range
Age (years)		36.13 ± 8.71 (18-63)
Gender, n (%)	Male	61 (70.9)
	Female	25 (29.1)
Donor type, n (%)	Living related	11 (12.8)
	Living unrelated	75 (87.2)
Causes of end-stage renal disease, n (%)	Chronic glomerulonephritis	83 (96.5)
	Pyelonephritis	3 (3.5)
HLA mismatch		3.38 ± 1.12 (1-6)
Height (cm)		163.76 ± 6.44 (145-176)
Weight (kg)		54.15 ± 8.38 (40-89)
BMI (kg/m2)		20.16 ± 2.71 (15.6-34.5)
Creatinine pre-transplantation (μmol/L) (n = 85)		847.46 ± 541.29 (375.00-5444.70)
Creatinine post-transplantation (μmol/L)
Day 1 (n = 80)		630.33 ± 191.09 (232.30-1216.15)
Day 2 (n = 86)		362.83 ± 159.12 (124.80-893.71)
Day 3 (n = 84)		179.59 ± 118.19 (68.60-653.88)
Day 4 (n = 83)		136.35 ± 82.07 (51.30-542.60)
Day 5 (n = 68)		125.38 ± 76.48 (59.90-499.02)
Day 6 (n = 69)		116.43 ± 66.98 (58.60-491.73)
Day 7 (n = 83)		104.67 ± 46.09 (53.50-337.06)
eGFR pre-transplantation (mL/minute) (n = 85)		8.70 ± 2.64 (1.15-18.88)
eGFR post-transplantation (mL/minute)
Day 1 (n = 80)		11.49 ± 4.19 (5.38-25.53)
Day 2 (n = 86)		21.16 ± 9.13 (8.23-61.43)
Day 3 (n = 84)		45.11 ± 16.57 (10.84-84.24)
Day 4 (n = 83)		55.83 ± 16.89 (13.07-103.74)
Day 5 (mL/minute) (n = 68)		60.06 ± 16.91 (14.77-109.33)
Day 6 (mL/minute) (n = 69)		63.39 ± 16.01 (14.42-102.14)
Day 7 (mL/minute) (n = 83)		69.13 ± 17.83 (25.15-141.30)
Delayed graft function, n (%)		1 (1.2)
Clinical acute rejection, n (%)	Yes	1 (1.2)
	No	85 (98.8)
CYP3A5, n (%)	CYP3A51/1	9 (10.5)
	CYP3A51/3	40 (46.5)
	CYP3A53/3	37 (43.0)

HLA: Human leucocyte antigen; BMI: Body mass index; eGFR: Estimated glomerular filtration rate.