Clinical events and healthcare resource utilization associated with neutropenia and leukopenia among adult kidney transplant recipients receiving valganciclovir

doi:10.5500/wjt.v15.i2.102671

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 18, 2025; 15(2): 102671
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.102671

Table 5 Healthcare resource utilization by year after kidney transplantation

All-cause healthcare resource utilization	Year 1, n = 15390¹		Year 2-5, n = 34513²
All-cause healthcare resource utilization	With leukopenia/neutropenia, n = 11516	Without leukopenia/neutropenia, n = 3874	With leukopenia/neutropenia, n = 9264	Without leukopenia/neutropenia, n = 25249
Inpatient
Patients with admission, n (%)	7441 (64.61)	2205 (56.92)	3408 (36.79)	6471 (25.63)
Number of admissions, mean ± SD (median)	3.47 ± 5.07 (2)	2.76 ± 3.63 (2)	2.70 ± 3.01 (2)	2.29 ± 2.57 (1)
Length of stay (days) among patients who had ≥ 1 admission, mean ± SD (median)	6.68 ± 27.26 (4)	7.55 ± 36.70 (4)	7.50 ± 29.83 (4.5)	5.92 ± 24.40 (3)
Emergency department/other
Patients with visits, n (%)	3383 (29.38)	988 (25.50)	1927 (20.80)	4036 (15.98)
Number of visits, mean ± SD (median)	1.81 ± 1.37 (1)	1.74 ± 1.43 (1)	1.87 ± 1.69 (1)	1.77 ± 1.65 (1)
Outpatient
Patients with visits, n (%)	11304 (98.16)	3813 (98.43)	9130 (98.55)	24460 (96.88)
Number of visits, mean ± SD (median)	48.97 ± 37.34 (37)	34.42 ± 28.18 (25)	31.73 ± 27.63 (25)	15.59 ± 18.53 (9)
Other³
Patients with other visits, n (%)	162 (1.41)	74 (1.91)	122 (1.32)	442 (1.75)
Number of other visits, mean ± SD (median)	2.85 ± 7.62 (1)	5.05 ± 12.84 (1.5)	3.25 ± 3.84 (2)	2.17 ± 2.11 (1)
Unknown
Patients with visits, n (%)	7702 (66.88)	2142 (55.29)	7473 (80.67)	14820 (58.70)
Number of visits, mean ± SD (median)	36.74 ± 31.57 (28)	28.27 ± 30.78 (16)	17.85 ± 18.30 (13)	13.48 ± 16.19 (8)
Any labs
Patients with any labs, n (%)	11475 (99.64)	3832 (98.92)	9264 (100.00)	25249 (100.00)
Number of any labs, mean ± SD (median)	1654.55 ± 984.16 (1485)	1182.27 ± 755.58 (1084)	622.37 ± 706.25 (419)	327.89 ± 374.36 (222)

¹The n represented the number of patients with a full year of follow-up during year 1.

²The n represented the number of patient observations with a full year of follow-up during years 2-5. Patients with multiple full years of follow-up were counted for each year.

³Other visits included home health visits, pre-admission encounters, and virtual visits.

Citation: Beyer AP, Moise PA, Wong M, Gao W, Xiang C, Shen P, Pavlakis M, Vincenti F, Wang W. Clinical events and healthcare resource utilization associated with neutropenia and leukopenia among adult kidney transplant recipients receiving valganciclovir. World J Transplant 2025; 15(2): 102671
URL: https://www.wjgnet.com/2220-3230/full/v15/i2/102671.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i2.102671