Novel association between graft rejection and post-transplant malignancy in solid organ transplantation

Table 6 Time-dependent Cox proportional hazards regression analysis of rejection-induced graft failure risk in post-transplant malignancy

Covariate (Time-dependent)	Transplant organ	Rejection-induced graft failure risk
		Univariate		Multivariate1
		HR (95%CI)	P value	HR (95%CI)	P value
Post-transplant malignancy	Total	0.81 (0.78-0.84)	< 0.001	1.11 (1.07-1.15)	< 0.001
	Kidney	0.81 (0.78-0.85)	< 0.001	1.14 (1.10-1.19)	< 0.001
	Liver	0.64 (0.50-0.81)	< 0.001	0.93 (0.67-1.29)	0.67
	Heart	0.58 (0.50-0.69)	< 0.001	0.83 (0.69-0.99)	0.04
	Lung	1.04 (0.96-1.13)	0.30	1.11 (1.02-1.21)	0.02
	Pancreas	1.07 (0.49-2.33)	0.87	1.16 (0.50-2.69)	0.74
Excluding malignancy-related mortality	Total	0.50 (0.47-0.52)	< 0.001	0.69 (0.65-0.73)	< 0.001
	Kidney	0.65 (0.62-0.69)	< 0.001	0.90 (0.84-0.95)	< 0.001
	Liver	0.15 (0.08-0.27)	< 0.001	0.21 (0.11-0.38)	< 0.001
	Heart	0.15 (0.10-0.22)	< 0.001	0.21 (0.14-0.31)	< 0.001
	Lung	0.17 (0.13-0.22)	< 0.001	0.18 (0.14-0.23)	< 0.001
	Pancreas	1.30 (0.57-3.01)	0.54	1.62 (0.69-3.77)	0.27

¹Multivariate analysis adjusted for age, sex, race/ethnicity, body mass index, performance status, ABO blood group, ABO match status, human leukocyte antigen match status, oncogenic virus seropositivity, donor type, and immunosuppressive therapy.

CI: Confidence interval; HR: Hazard ratio.