Novel association between graft rejection and post-transplant malignancy in solid organ transplantation

doi:10.5500/wjt.v15.i2.102384

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Jun 18, 2025 (publication date) through Feb 21, 2025

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Transplant. Jun 18, 2025; 15(2): 102384
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.102384

Table 5 Landmark analysis of rejection-induced graft failure risk in post-transplant malignancy, n (%)

Variable	Rejection-induced graft failure	Rejection-induced graft failure risk
		Univariate		Multivariate¹
		HR (95%CI)	P value	HR (95%CI)	P value
Post-transplant malignancy
No landmark (n = 69838)	3973 (5.69)	0.35 (0.34-0.36)	< 0.001	0.42 (0.40-0.43)	< 0.001
1-year landmark (n = 13945)	710 (5.09)	0.60 (0.56-0.65)	< 0.001	0.85 (0.79-0.92)	< 0.001
2-year landmark (n = 18856)	983 (5.21)	0.60 (0.57-0.64)	< 0.001	0.85 (0.80-0.91)	< 0.001
3-year landmark (n = 22758)	1155 (5.08)	0.59 (0.55-0.62)	< 0.001	0.84 (0.79-0.89)	< 0.001
5-year landmark (n = 26630)	1336 (5.02)	0.59 (0.56-0.63)	< 0.001	0.84 (0.79-0.89)	< 0.001
10-year landmark (n = 24023)	1152 (4.80)	0.69 (0.65-0.73)	< 0.001	0.89 (0.84-0.95)	< 0.001
15-year landmark (n = 14884)	667 (4.48)	0.88 (0.81-0.96)	0.003	1.06 (0.97-1.16)	0.22
20-year landmark (n = 7581)	283 (3.73)	0.99 (0.87-1.14)	0.93	1.12 (0.96-1.31)	0.14
Excluding malignancy-related mortality
No landmark (n = 29830)	1332 (4.47)	0.25 (0.24-0.26)	< 0.001	0.31 (0.29-0.33)	< 0.001
1-year landmark (n = 6596)	214 (3.24)	0.34 (0.30-0.39)	< 0.001	0.51 (0.44-0.58)	< 0.001
2-year landmark (n = 9060)	277 (3.06)	0.32 (0.28-0.36)	< 0.001	0.49 (0.44-0.56)	< 0.001
3-year landmark (n = 10943)	327 (2.99)	0.31 (0.28-0.35)	< 0.001	0.49 (0.44-0.55)	< 0.001
5-year landmark (n = 12790)	422 (3.30)	0.36 (0.32-0.39)	< 0.001	0.56 (0.50-0.61)	< 0.001
10-year landmark (n = 11564)	423 (3.66)	0.48 (0.44-0.53)	< 0.001	0.67 (0.60-0.74)	< 0.001
15-year landmark (n = 7287)	270 (3.71)	0.66 (0.59-0.75)	< 0.001	0.80 (0.70-0.91)	< 0.001
20-year landmark (n = 3587)	124 (3.46)	0.77 (0.64-0.93)	0.01	0.84 (0.68-1.03)	0.10

¹Multivariate analysis adjusted for age, sex, race/ethnicity, body mass index, performance status, ABO blood group, ABO match status, human leukocyte antigen match status, oncogenic virus seropositivity, donor type, and immunosuppressive therapy.

CI: Confidence interval; HR: Hazard ratio.

Citation: Kim HS, Woo W, Choi YG, Bharat A, Chae YK. Novel association between graft rejection and post-transplant malignancy in solid organ transplantation. World J Transplant 2025; 15(2): 102384
URL: https://www.wjgnet.com/2220-3230/full/v15/i2/102384.htm
DOI: https://dx.doi.org/10.5500/wjt.v15.i2.102384