Novel association between graft rejection and post-transplant malignancy in solid organ transplantation

Table 4 Time-dependent Cox proportional hazards regression analysis of post-transplant malignancy risk in rejection-induced graft failure

Covariate (Time-dependent)	Transplant organ	Post-transplant malignancy risk
		Univariate		Multivariate1
		HR (95%CI)	P value	HR (95%CI)	P value
Rejection-induced graft failure	Total	0.12 (0.11-0.13)	< 0.001	0.21 (0.19-0.24)	< 0.001
	Kidney	0.14 (0.12-0.16)	< 0.001	0.21 (0.18-0.23)	< 0.001
	Liver	0.50 (0.13-2.01)	0.33	0.001 (0.00-7.31E+17)	0.79
	Heart	0.29 (0.07-1.17)	0.08	0.52 (0.13-2.06)	0.35
	Lung	0.44 (0.24-0.82)	0.01	0.44 (0.22-0.89)	0.02
	Pancreas	0.19 (0.03-1.33)	0.09	0.20 (0.03-1.44)	0.11
Excluding rejection-related retransplantation	Total	0.14 (0.12-0.16)	< 0.001	0.23 (0.20-0.26)	< 0.001
	Kidney	0.17 (0.15-0.19)	< 0.001	0.22 (0.20-0.26)	< 0.001
	Liver	0.78 (0.20-3.13)	0.73	0.96 (0.24-3.85)	0.96
	Heart	0.18 (0.03-1.30)	0.09	0.29 (0.04-2.03)	0.21
	Lung	0.44 (0.22-0.88)	0.02	0.46 (0.23-0.91)	0.03
	Pancreas	0.28 (0.04-2.03)	0.21	0.31 (0.04-2.25)	0.25
Excluding rejection-related mortality	Total	0.11 (0.09-0.13)	< 0.001	0.25 (0.21-0.31)	< 0.001
	Kidney	0.13 (0.11-0.16)	< 0.001	0.25 (0.20-0.31)	< 0.001
	Liver	0.05 (0.00-68.29)	0.42	0.004 (0.00-2.86E+11)	0.74
	Heart	0.49 (0.07-3.46)	0.47	0.82 (0.12-5.83)	0.84
	Lung	0.55 (0.18-1.72)	0.31	0.77 (0.25-2.37)	0.64
	Pancreas	0.05 (0.00-8.78)	0.25	0.00 (0.00-9.80E+190)	0.96

¹Multivariate analysis adjusted for age, sex, race/ethnicity, body mass index, performance status, ABO blood group, ABO match status, human leukocyte antigen match status, oncogenic virus seropositivity, donor type, and immunosuppressive therapy.

CI: Confidence interval; HR: Hazard ratio.