Novel association between graft rejection and post-transplant malignancy in solid organ transplantation

Table 2 Post-transplant clinical outcomes, n (%)

Variable	Transplant organ type						P value
	Total	Kidney	Liver	Heart	Lung	Pancreas
Number of patients	579905	386878	108390	45046	37643	1948
Rejection-induced graft failure	55240 (9.5)	46815 (12.1)	1951 (1.8)	1770 (3.9)	4505 (12.0)	199 (10.2)	< 0.001
Acute rejection graft failure	12282 (2.1)	10424 (2.7)	746 (0.7)	646 (1.4)	302 (0.8)	164 (8.4)	< 0.001
Chronic rejection graft failure	43175 (7.4)	36391 (9.4)	1422 (1.3)	1124 (2.5)	4203 (11.2)	35 (1.8)	< 0.001
Retransplantation	36636 (6.3)	30367 (7.8)	4069 (3.8)	781 (1.7)	1214 (3.2)	205 (10.5)	< 0.001
Post-transplant malignancy	69838 (12.0)	38302 (9.9)	13414 (12.4)	9397 (20.9)	8505 (22.6)	220 (11.3)	< 0.001
Breast cancer	2706 (0.5)	1867 (0.5)	453 (0.4)	198 (0.4)	176 (0.5)	12 (0.6)	0.054
Digestive cancer	6696 (1.2)	3450 (0.9)	1771 (1.6)	722 (1.6)	745 (2.0)	8 (0.4)	< 0.001
Genitourinary cancer	9595 (1.7)	6114 (1.6)	1339 (1.2)	1490 (3.3)	639 (1.7)	13 (0.7)	< 0.001
Gynecologic cancer	708 (0.1)	492 (0.1)	121 (0.1)	35 (0.1)	55 (0.1)	5 (0.3)	0.008
Head and neck cancer	1853 (0.3)	941 (0.2)	546 (0.5)	204 (0.5)	159 (0.4)	3 (0.2)	< 0.001
Hematologic cancer	8094 (1.4)	4325 (1.1)	1808 (1.7)	918 (2.0)	995 (2.6)	48 (2.5)	< 0.001
Musculoskeletal cancer	329 (0.1)	177 (0.0)	59 (0.1)	41 (0.1)	50 (0.1)	2 (0.1)	< 0.001
Neurologic cancer	42 (0.0)	29 (0.0)	4 (0.0)	3 (0.0)	6 (0.0)	0 (0.0)	0.198
Respiratory cancer	6523 (1.1)	2980 (0.8)	1532 (1.4)	1089 (2.4)	911 (2.4)	11 (0.6)	< 0.001
Skin cancer/Kaposi sarcoma	37061 (6.4)	19411 (5.0)	6230 (5.7)	5763 (12.8)	5529 (14.7)	128 (6.6)	< 0.001
Unknown primary cancer	572 (0.1)	330 (0.1)	101 (0.1)	74 (0.2)	66 (0.2)	1 (0.1)	< 0.001
Other cancer	6093 (1.1)	3322 (0.9)	1276 (1.2)	733 (1.6)	734 (1.9)	28 (1.4)	< 0.001
Death	228813 (39.5)	148606 (38.4)	39082 (36.1)	18542 (41.2)	22030 (58.5)	553 (28.4)	< 0.001