King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

Figure 4 Liver histopathological analysis. Histopathological features of explanted livers from Yellow fever (YF) patients who underwent transplantation. A and B: Microscopic examination showing a midzonal lesion (arrows) with acidophilic bodies, steatotic hepatocytes (asterisk), hyperplasia and hypertrophy of Kupffer cells, and mild inflammation, mainly in the portal tracts. Note the periportal preservation of hepatocytes; C: YF virus antigen positivity in midzonal hepatocytes with acidophilic degeneration or steatosis and in Kupffer cells.