King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

Table 4 Correlations between international normalized ratio, factor V, onset day of neurological symptoms, neurological symptoms, and outcomes in patients with acute liver disease due to yellow fever at Felicio Rocho Hospital between January 20 and February 20, 2018 (n = 14)

Cases	Concentrated fresh plasma	D4	D5	D6	D7	D8	D9	D10	D12	D14	D4	D5	D6	D7	D8	D9	D10	D12	D14	Day of onset of neurological symptoms	Neurological symptoms	Outcome
		International normalized ratio									Factor V (%)
Case 1	Yes	-	-	-	-	1.7	-	1.2	-	2.9	-	-	-	-	-	-	-	-	-	D10	Initial slowing with rapid progression to stupor and coma	Death
Case 9	Yes	> 7	5.5	-	-	-	-	-	-	-	-	8.8	-	-	-	-	-	-	-	D5	Drowsiness and flapping with rapid progression to coma	Death
Case 12	Yes	-	-	4.4	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	D5	Drowsiness, disorientation, progression to stupor and coma	Death
Case 13	Yes	2	2.2	3	2.7	-	-	-	-	-	16.6	22.4	-	-	-	-	-	-	-	D5	Recurrent seizures	Death
Case 4	Yes	4.1	6.6	7.9	> 9	-	-	-	-	-	-	-	15.6	-	-	-	-	-	-	D6	Agitation was intubated due to respiratory failure	Transplant
Case 8	No	-	2.3	2	-	-	-	-	-	-	15.8	21.5	-	-	-	-	-	-	-	D5	Slowing and mild disorientation	Transplant
Case 11	Yes	-	> 9	> 10	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	D4	Drowsiness and flapping with rapid progression to coma	Transplant
Case 14	Yes	-	2.6	2.7	2	2.4	2.9	2.1	-	-	-	-	21	21.7	21.5	12.8	-	-	-	D9	Slowing, flapping, progression to stupor and coma	Transplant
Case 2	No	1.1	1.1	1	1	1	-	-	-	-	-	-	-	-	161	-	-	-	-	-		Clinical improvement
Case 3	No	1	1	1	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-		Clinical improvement
Case 5	No	1.6	1.8	1.7	1.6	1.4	1.3	1.3	-	1.2	-	-	-	-	-	-	-	158	-	D10		Clinical improvement
Case 6	No	-	-	1.7	1.7	1.5	-	-	-	1.1	81.6	-	-	-	-	-	-	-	-	-		Clinical improvement
Case 7	No	1.4	1.5	1.6	1.7	1.6	1.4	1.4	-	1.2	44.4	-	-	-	-	-	-	-	-	D9	Mental confusion and disorientation, complete recovery. Bacterial sepsis	Clinical improvement
Case 10	No	1.2	1.1	1	1	1	1.1	1.1	-	-	-	-	-	-	-	-	-	-	-	-		Clinical improvement

D4: Day 4; D5: Day 5; D6: Day 6; D7: Day 7; D8: Day 8; D9: Day 9; D10: Day 10; D12: Day 12; D14: Day 14.