New frontiers in retinal transplantation

doi:10.5500/wjt.v14.i4.97690

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Dec 18, 2024 (publication date) through Oct 5, 2024

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Dec 18, 2024; 14(4): 97690
Published online Dec 18, 2024. doi: 10.5500/wjt.v14.i4.97690

Table 1 Scaffolding with stem cell-derived cells

Scaffold	Characteristics	Disease	ETDRS improvement (letters)
	hESC-RPE: 50-150000 cells	Dry AMD	12
PET	hESC-RPE (approximately 100000) on 10 µm-thick PET, coated with plasma-derived vitronectin; Non-biodegradable	Wet AMD	21
Parylene	hESC-RPE (approximately 100000) on ultrathin (0.3 µm-thick), parylene membrane on a perforated, 6 µm-thick parylene support; Biodegradable	Dry AMD	17
PLGA	hiPSC-RPE (approximately 100000) on 10 µm-thick, electrospun PLGA with 350 nm mean fiber diameter; Biodegradable	Dry AMD	In progress
hiPSC- secreted basal membrane	hiPSC-RPE on PET coated with a collagen-I gel; Confluent sheets released from PET with collagenase Biodegradable	Wet AMD	No change

AMD: Age-related macular degeneration; hESC-RPE: Retinal pigment epithelium derived from human embryonic stems cells; hiPSC-RPE: Retinal pigment epithelium derived from human induced pluripotent cells; PET: Polyethylene terephthalate; PLGA: Lactic-co-glycolic acid.

Citation: Sorrentino FS, Di Terlizzi P, De Rosa F, Salati C, Spadea L, Gagliano C, Musa M, Zeppieri M. New frontiers in retinal transplantation. World J Transplant 2024; 14(4): 97690
URL: https://www.wjgnet.com/2220-3230/full/v14/i4/97690.htm
DOI: https://dx.doi.org/10.5500/wjt.v14.i4.97690