SIMAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

Table 5 Comparison between SIMAP500 and RETREAT scoring systems

Characteristic	SIMAP500 score	RETREAT score
Consider the presence of satellite nodules on explant histology	Yes	No
Consider the tumour differentiation grade on explant histology	Yes	No
AFP capture	At listing with a cutoff point of 500	At LT with AFP divided into four intervals (very wide range between 100-999 receiving 2 points)
Consider the increase in the size of the tumour while on the waiting list	Yes	No
Consider microvascular invasion on explant histology	Yes	Yes
AUC	0.807	0.703

RETREAT: Risk Estimation of Tumor Recurrence After Transplant; SIMAP500: Satellite nodules, Increase in size, Microvascular invasion, AFP > 500, Poor differentiation; LT: Liver transplantation; AFP: Alpha fetoprotein; AUC: Area under the curve.